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 Prof. Michael Davies-Coleman

Position: Dean of Science
Faculty: Faculty of Natural Science
Qualifications: BSc, BSc(Hons), PhD (Rhodes)
Tel: 021 959 2255
Fax: 021 959 2266


 Professor Mike Davies-Coleman joined the University of Western Cape as the Dean of Natural Sciences from Rhodes University in June 2012. Professor Davies-Coleman, an organic chemist, is an NRF B-rated researcher and has supervised and co-supervised 26 MSc and PhD graduates in thefields of marine and plant natural products chemistry and other aspects of organic chemistry. He is regarded as a leading authority on African marine natural products with several on-going international collaborations and has published over 100 research publications in plant and marineinvertebrate natural products chemistry and other related organic chemistry fields. Professor Davies-Coleman is a Fellow of the Royal Society of South Africa and the South African Chemical Institute. While at Rhodes University he was the recipient of both the Vice Chancellor Distinguished Research and Teaching Awards. During his academic career he has been awarded US National Institutes of Health and Fulbright Senior Research Fellowships to carry out research at the National Cancer Institute in the USA (1999 and 2005) and more recently a Benjamin Meaker Visiting Fellowship to the University of Bristol in the UK (2018).


Research publications 2012-2019

1.Exploratory applications of 2-nitrobenzaldehyde-derived Morita–Baylis–Hillman adducts as synthons in the construction of drug-like scaffolds, Idahosa, K.C., Davies-Coleman, M.T., Kaye, P. T., Synthetic Communications, 2019, doi: 10.1080/00397911.2018.1559333, (Impact factor = 1.0).

2.Hyphenated LC-ICP-MS/ESI-MS identification of iodinated metabolites in South African marine ascidian extracts Bromley, C.L.; Raab, A.; Parker-Nance, S.; Beukes, D.R.; Jaspars, M and Davies-Coleman, M. T.  South African Journal of Chemistry, 2018, 71, 111-117.

3.Four decades of trace gas analysis at Cape Point, South Africa. Labuschagne, C.;  Kuyper, B.; Brunke, E-G.; Mokolo,T.;  van der Spuy, D.;  Martin, L.;  Mbambalala, E.;  Parker, B.; Khan, M.A.H.; Davies-Coleman, M.T.; Dudley E. Shallcross, D. E. and Joubert, W. Transactions of the Royal Societry of South Africa, 2018, 73, 113-132.

4.Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box Milanowski, D. J., Oku, N.,  Cartner, L. K., Bokesch, H. R., , R. T.,  Saurí, J., Liu, Y., Blinov, K.A. Ding, Y., Li, X-C.,  Ferreira, D., Walker,  L.A., Khan, S.,  Davies-Coleman, M.T.,  Kelly, J.A., McMahon, J.B. Martin, G. A.,  and Gustafson, K.R. Chemical Science, 2018, 9, 307 - 314, DOI: 10.1039/c7sc01996c.

5.Antibacterial activities of bacteria isolated from the marine sponges Isodictya compressa and Higginsia bidentifera collected from Algoa Bay, South Africa. Matobole R. H, van Zyl, L.J., Parker-Nance, S. Davies-Coleman, M.T.,  Trindade, M., Marine Drugs, 2017 15, 47; doi:10.3390/md15020047

6.Keeping it in the family: Evidence for co-evolution of latrunculid sponges and their dominant bacterial symbionts.Matcher, G.F., Waterworth, S.C., Walsmley, T. A., Matsatsa, T., Parker-Nance, S., Davies-Coleman, M.T. and Dorrington, R.A. Microbiology Open, 2017, 6, 1-13. Doi:10.1002/mbo3.417

7.A modelling study of the atmospheric chemistry of DMS using the global model, STOCHEM-CRI.Khan M.A.H., Gillespie S.M.P., Razis B., Xiao P., Davies-Coleman M.T., Percival, C.J., Derwent, R.G., Dyke, J.M., Ghosh, M.V., Lee, E.P.F. and Shallcross, D.E. Atmospheric Environment, 2016, 127, 69-79.

8. Recent advances in drug discovery from South African marine invertebrates. Davies-Coleman, M.T. and Veale, C.G.L Marine Drugs, 2015, 13, 6366-6383. (Impact Factor = 3.45)

9.Antiplasmodial activity: The first proof of inhibition of heme crystallization by marine isonitriles.Young, R.M., Adendorff, M.R., Wright, A.D. and Davies-Coleman, M.T. European Journal of Medicinal Chemistry 2015, 93, 373-380.

10.Synthetic Analogues of Marine Bisindole Deoxytopsentin: Potent Selective Inhibitors of MRSA Pyruvate Kinase. Veale, C.G.L.,  Zoraghi, R., Young, R. M., Morrison, J. P., Partheeban, M., Lobb, K. A., Reiner, N. E., Andersen, R. J. and Davies-Coleman, M.T. Journal of Natural Products 2015, 78, 355-362.

11.Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues.Veale, C.G.L., Lobb, K.A., Zoraghi, R., Reiner, N.E., Andersen, R.J. and Davies-Coleman, M.T. Tetrahedron, 2014, 70, 7845-7853.

12.Marine Bi-, Bis- and Trisindole Alkaloids. Veale, C.G.L. and Davies-Coleman, M.T. In: “The Alkaloids” Vol 73 H.J. Knolcker (Ed), Elsevier, Burlington Academic press, 2014 pp 1-64.

13.Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.Sunassee, S.N.,  Veale, C.G.L,  Shunmoogam-Gounden, N., Osoniyi, O.,  Hendricks, D.T.,  Caira, M.R.,  de la Mare, J-A., Edkins, A.L.,  Pinto, A.V.,  da Silva Júnior, E.N. and Davies-Coleman M.T. European Journal of Medicinal Chemistry 2013, 62, 98-110.

14. New oxindole from the South African marine ascidian Distaplia skoogi. Bromley, C.L., Parker-Nance, S., De La Mare J., Edkins A.L., Beukes, D.R. and Davies-Coleman, M.T. South African Journal of Chemistry 2013, 66, 64-68.

15.The implementation of a service-learning component in an organic chemistry laboratory course. Glover, S., Sewry, J., Bromley,C.; Davies-Coleman, M., Hlengwa, A. Journal of Chemical Education 2013, 90, 578-583.

16.Innovative processes and products involving marine organisms. Bolton J.J.; Davies-Coleman, M.T. and Coyne V.E. African Journal of Marine Science, 2013, 35, 449-464.

17.Antimicrobial rubolides P-S from a South African species of Synocium tunicate. Sikorska, J., Parker-Nance, S., Davies-Coleman, M.T., Vining, O.B., Sikora, A.E. and McPhail, K.L. Journal of Natural Products, 2012, 75, 1824-1827.

18.Mandelalides A-D, cytotoxic macrolides from a new Lissoclinum species of South African tunicate. Sikorska,, J., Hau, A.M., Anklin, C.,  Parker-Nance, S.,  Davies-Coleman, M.T.,  Ishmael, J.E., McPhail, K.L. Journal of  Organic Chemistry, 2012,77, 6066-6075.

19.Gordon M. Cragg, D Phil., D.D.Sc. (h.c.): A Man for All Natural Products. Bolzani V. d S; Davies-Coleman, M.T., Newman, D.J. and Singh, S.B. Journal of Natural Products, 2012, 75, 309-310.

20.Cytotoxic and anti-oxidant marine prenylated quinones and hydroquinones. Sunassee, S.N. and Davies-Coleman M.T. Natural Product Reports 2012, 29, 513-535

21.Polypropionates from the South African Marine Mollusk Siphonaria oculus. Bromley, C. L., Popplewell W. L., Pinchuck, S.C., Hodgson, A. N. and Davies-Coleman, M. T. Journal of Natural Products, 2012, 75, 497-501.

22.Diversity of bacterial communities associated with the Indian Ocean sponge Tsitsikamma favus that contains the bioactive pyrroloiminoquinones, tsitsikammamine A and B. Walmsley, T.A., Matcher, G.F., Zhang, F., Hill, R.T., Davies-Coleman, M.T. and Dorrington, R.A. Marine Biotechnology , 2012,14, 681-691.

23.Marine Bioprospecting in Southern Africa. Sunassee, S.N. and Davies-Coleman, M.T. In: “Drug Discovery in Africa.”  K. Chibale, C. Masimbirembwe and M.T. Davies-Coleman (Eds), Springer-Verlag, Heidelberg 2012 pp 193-210.







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