Research Ethics

Research Ethics refers to the moral principles and rules guiding scientific investigations. It ensures the protection of humans and animals.
https://www.niehs.nih.gov/research/resources/bioethics/whatis

Core Principles include

  • Beneficence & Non-Maleficence: Striving to maximize benefits and minimize harm to participants, the environment, and society.
  • Respect for Persons: Upholding participant autonomy (e.g., through informed consent) and protecting vulnerable populations.
  • Justice: Ensuring fair distribution of the benefits and burdens of research, and treating all subjects equitably.
  • Integrity & Honesty: Striving for transparency in reporting data, methods, and results without manipulating findings

https://www.niehs.nih.gov/research/resources/bioethics/whatis

The University of the Western Cape has three Research Ethics Committee’s (REC’s) under Senate. The primary role of the UWC REC’s is to protect the interests (rights and welfare) of the research participants who volunteer to take part, or to protect the interests and welfare of the animals used, in scientifically and ethically sound research, respectively in accordance with the National Health Research Ethics Council (NHREC) Guidelines:

The AREC’s responsibility is to ensure the humane treatment of animals in scientific studies and that the potential scientific benefits outweigh the harm to the animals and/or that researchers minimize suffering in accordance with the South African National Standard for care and use of animals SANS 10386 (2021).

4 R’s

  • Replacement: Seeking alternative methods (like computer models or cell cultures) to avoid using live animals entirely.
  • Reduction: Designing experiments to use the fewest number of animals possible while still yielding valid statistical data.
  • Refinement: Adjusting experimental procedures to minimize pain, distress, and discomfort, and to enhance animal living conditions.
  • Responsibility: All stakeholders must take responsibility for the research animals  

5 Freedoms

  • Freedom from hunger and thirst
  • Freedom from pain, injury and disease
  • Freedom from suffering
  • Freedom from discomfort
  • Freedom to express natural behaviors
AREC Instructions for Applicants 2026
AREC-T Application to use animal material form 2026
AREC-R Reciprocal acknowledgement form 2026
AREC-M Full application form 2026 
AREC-L Lower invertebrates application form 2026
AREC-E Adverse event report form 2026
AREC-D Application to use previously collected data Form 2026
AREC-APR Annual progress or final report form 2026
AREC-A Amendment application form 2026
AREC Meeting Dates 2026

The Biomedical Research Ethics Committee (BMREC) of the University of the Western Cape (UWC) is an independent ethics review committee responsible for ensuring that biomedical and health-related research involving human participants is conducted ethically, responsibly, and in accordance with national and international ethical standards.

BMREC's primary mandate is to protect the rights, dignity, safety, and wellbeing of research participants while promoting high-quality, scientifically sound research. The Committee reviews research protocols submitted by UWC researchers, students, and collaborators to ensure compliance with applicable ethical, legal, and regulatory requirements, including the South African National Health Act, Department of Health Ethics Guidelines, and Good Clinical Practice (GCP) standards where applicable.

As a service to the UWC research community, BMREC provides ethical review, guidance, oversight, and monitoring of biomedical research throughout the research lifecycle. Through its activities, BMREC supports the University's commitment to research excellence, integrity, innovation, and social responsibility.

For the purposes of BMREC review, biomedical research refers broadly to research involving human participants, their biological materials, personal health information, or interventions aimed at understanding health, disease, prevention, diagnosis, treatment, rehabilitation, or wellbeing. This includes clinical, laboratory, epidemiological, public health, and related health sciences research.

BMREC Sub Study Ethics Applicaiton Form 2026
BMREC Resubmission Form 2026
BMREC Reciprocal Ethics Application Form 2026
BMREC Query Complaints Form 2026
BMREC Main Ethics Application Form 2026
BMREC Data Management Plan 2026
BMREC Application for Amendment Form 2026
BMREC Annual or Final Report Form 2026
BMREC Meeting Dates 2026