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Head of School

Position: Director - School of Pharmacy
List of Qualifications: B.Pharm, M.Sc., DTE, Ph.D.
Telephone: 021 959 3190
Email: sfmalan@uwc.ac.za

Biography

Professor and Director of the School of Pharmacy, University of the Western Cape;  Fellow of the Pharmaceutical Society of South Africa and Honorary Life Member of the Academy of Pharmaceutical Sciences. 

Served in various capacities on executive committees of the Academy of Pharmaceutical Sciences (Secretary, Treasurer, Vice Chair and Chair) and Pharmaceutical Society of South Africa (Branch Chair, Vice President, Deputy President and President).  Current Chair of the International Non-proprietary Names (INN) Committee of WHO and member of the South African Pharmacy Council and expert committees of the South African Health Products Regulatory Authority (SAHPRA).

Supervised or co-supervised more than 75 M.Sc. and Ph.D. studies in Pharmaceutical/Medicinal Chemistry and Pharmaceutics. Published published 100+ scientific papers, 25+ perspective columns/comments in the SA Pharmacy Journal, have ±150 national and international conference contributions; and is National Research Foundation (NRF) B3 rated scientist.

Acted as external examiner and moderator for undergraduate courses, M.Sc. dissertations and Ph.D. thesis for National University of Singapore, University of Namibia, Nelson Mandela University, University of KwaZulu-Natal, University of the Western Cape, Rhodes University, North-West University, University of Pretoria, University of the Witwatersrand, National University of Lesotho and the South African Pharmacy Council,.
Editorial Board Member of Mini-Reviews in Medicinal Chemistry and The Open Medicinal Chemistry Journal (TOMCJ), Bentham Scientific Publishers.  Reviewer/Evaluator for National Research Foundation (Rating and Funding), South African Journal of Science, Organic Letters, Life Sciences, Letters in Organic Chemistry, Metabolic Brain Disease, Bioorganic and Medicinal Chemistry, European Journal of Medicinal Chemistry and European Journal of Pharmacology.

Current research interests are in drug design and molecular modelling of novel entities with ion channel and/or neuroprotective activity, antimalarial and antimicrobial activity or resistance reversal, and the influence of chemical structure and conformation on physicochemical properties and membrane permeability of drugs as well as the design of hybrid and pro-drugs with multitarget-directed activity.

 
Committees served on:

WHO Expert Advisory Panel on International Pharmacopoeia and Pharmaceutical Preparations. (Chair 2017 – current) 2007 – current.

South African Health Products Regulatory Authority (SAHPRA) - Pharmaceutical and Analytical Committee 2001 – 2023.

Names and Scheduling Committee 2017 – current.

South African Pharmacy Council 2018 – 2022.

Standards Development Working Group of Council for Higher Education (CHE) for BPharm degree. 2019 – 2023.

Executive Committee of the Pharmaceutical Society of South Africa. (Member, Vice President, Deputy President, President and Past-President) 1999 - 2020

Executive Committee of the Academy of Pharmaceutical Sciences. (Honorary secretary, Vice Chairman, Chairman) 1996 - 2014

Branch Committees of the Pharmaceutical Society of South Africa Northwest and Cape-Western Province. 1999 – current.

Standards Generating Body (SGB) for Pharmacy. 2003 – 2011.

Organising committee of “The First International Conference on Pharmaceutical and Pharmacological Sciences – South Africa”. 1995 – 1996.

Member of South African Pharmacy Council Inspection Panel to Pharmacy Schools. 2003 – 2012.

Member of NRF Advisory Panel – Pharmaceutical and Biomedical Technology. 2004 – 2006.

Organising committee of the “Annual Symposium on Diseases Relevant to SA.” 2006 – 2008.

HESA representative on Steering committee of the drug discovery training programme between South Africa and Emory University, USA. 2008 – 2012.

Forum to promote transparency and multi stakeholder engagement regarding medicine availability, Department of Health, 2017 – 2022.

Recent Publications:

J. Joubert, N. Strydom, W.J. Geldenhuys, Y. Greyling, S. van Dyk, S.F. Malan.  2019.  Hexacyclododecylamines with sigma-1 receptor affinity and calcium channel modulating ability.  The Open Medicinal Chemistry Journal. 13:29-39.  DOI: 10.2174/1874104501913010029

S. Egieyeh, S.F. Malan, A. Christoffels.  2019.  Cheminformatic techniques in antimalarial drug discovery and development from natural products I: basic concepts.  Physical Sciences Reviews. 4(7):381-396.  DOI: 10.1515/psr-2018-0130.

F.T. Zindo, S.F. Malan, S.I. Omoruyi, A.B. Enogieru, O.E. Ekpo, J. Joubert.  2019  Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.  European Journal of Medicinal Chemistry. 163:83-94.  DOI: 10.1016/j.ejmech.2018.11.051.

J.S. Robertson, W-K. Chui, A.A. Genazzani, S.F. Malan, A. López de la Rica Manjavacas, G. Mignot, R. Thorpe, R. Balocco and M. Rizzi.  2019.  The INN Global Nomenclature of Biological Medicines: a continuous challenge.  Biologicals.  60:15-23.  DOI: 10.1016/j.biologicals.2019.05.006.

R. Sharma J. Joubert, H. Su, M.R. Caira, S.F. Malan.  2020.  Synthesis, crystal structure, DFT studies and biological evaluation of N-benzamido derivatives of oxahexacycloundecyl amines: a case of enantiomerism leading to molecular disorder.  Journal of Molecular Structure. 1215(2020):128248.  DOI: 10.1016/j.molstruc.2020.128248.

L.S. Zondagh, S.F Malan, J. Joubert.  2020.  Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents.  Journal of Enzyme Inhibition and Medicinal Chemistry. 35(1)1596-1605.  DOI: 10.1080/14756366.2020.1801673.

A.O Egunlusi, S.F. Malan, S.I. Omoruyi, O.E. Ekpo, V.A. Palchykov, J. Joubert.  2020.  Open and rearranged norbornane 1 derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP+- and calcium overload-induced excitotoxicity in neuroblastoma SH-SY5Y cells.  European Journal of Medicinal Chemistry.  204:112617.  DOI: 10.1016/j.ejmech.2020.112617.

A.O. Egunlusi, S.F. Malan, J. Joubert.  2020.  Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents.  Arkivoc.  DOI: 10.24820/ark.5550190.p011.302. 

A.O. Egunlusi, S.F. Malan, S.I. Omoruyi, O.E. Ekpo, J. Joubert.  2020.  4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as NMDA receptor- and VGCC blockers with neuroprotective potential.  Molecules. 25:4552.  DOI: 10.3390/molecules25194552.

S.A. Egieyeh, E.O. Egieyeh, S.F. Malan, A.G. Christoffels, B.C. Fielding.  2021.  Computational drug repurposing strategy predicted peptide based drugs that can potentially inhibit the interaction of SARS-CoV-2 Spike proteins with its target (humanACE2).  PLOS ONE 16(1): e0245258.  DOI: 10.1371/journal.pone.0245258.

E. Kapp, J. Joubert, S.L. Sampson, D.F. Warner, R. Seldon, A. Jordaan, M. de Vos, R. Sharma, S.F. Malan.  2021.  Antimycobacterial activity, synergism and mechanism of action evaluation of novel polycyclic amines against Mycobacterium tuberculosis.  Advances in Pharmacological and Pharmaceutical Sciences.  2021: 5583342. DOI: 10.1155/2021/5583342.

S. Egieyeh, S.F. Malan and A. Christoffels.  2021.  Cheminformatics techniques in antimalarial drug discovery and development from natural products 2: Molecular scaffold and machine learning approaches.  Physical Sciences Reviews.  6(3):20190029.  DOI: 10.1515/psr-2019-0029

S.C. Mzezewa, S.I. Omoruyi, L.S. Zondagh, S.F. Malan, O.E. Ekpo, J. Joubert.  2021.  Design, synthesis and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s Disease agents.  Journal of Enzyme Inhibition and Medicinal Chemistry.  36(1): 1607-1621.  DOI: 10.1080/14756366.2021.1913137.

S. Moodley, A, Gray, N Schellack et al.  2021.  Pharmacist-initiated management of antiretroviral therapy (PIMART).  South African Medical Journal.  111(12):1162-1163.

W-K Chui, S.F. Malan, G. Mignot, M. Rizzi, J.S. Robertson, A. López de la Rica Manjavacas, A. Romeo and R. Balocco.  2021.  International Nonproprietary Names: Translating the Science of Nomenclature into a Global Language for Education and Practice.  WHO Drug Information.  35(4):861-877.

A. Mester, G. Mignot, S.A.J. Lasseur, A. Romeo, S. Malan, S. Schubat, R. Balocco.  2021.  Prescribing with International Nonproprietary Names – facilitating communication and improving access to medical substances by increasing the use of non-originator pharmaceutical products. WHO Drug Information.  35(4):878-893.

R. Balocco, S. De Sousa Guimaraes Koch, R. Thorpe, K. Weisser, S. Malan.  2022.  New INN nomenclature for monoclonal antibodies. The Lancet.  399:24.

A. Kareem, S.F. Malan, J. Joubert.  2022.  Radical Releasing Anti-Tuberculosis Agents and the Treatment of Mycobacterial Tuberculosis Infections – An Overview.  Mini-Reviews in Medicinal Chemistry.  22(2):387-407.   DOI: 10.2174/1389557521666210219161045.   101

J. Joubert, S.F. Malan, W.J. Geldenhuys.  2022.  Editorial: Channel Modulation in Neurodegeneration and Neuroprotection.  Frontiers in Pharmacology.  13:872103.  DOI: 10.3389/fphar.2022.872103

S.S. Guimaraes Koch, R. Thorpe, N. Kawasaki, MP Lefranc, S. Malan, A. Martin, G. Mignot, A. Plückthun, M. Rizzi, S. Shubat, K. Weisser and R Balocco.  International Nonproprietary Names (INN) for monoclonal antibodies: an evolving nomenclature system.  mAbs.  14(1):e2075078.  DOI: 10.1080/19420862.2022.2075078.

E. Kapp, H. Calitz, E.M. Streicher, A. Dippenaar, S. Egieyeh, D.F. Warner, J. Joubert, S.F. Malan, S.L. Sampson.  Discovery and biological evaluation of an adamantyl-amide derivative with likely MmpL3 inhibitory activity.&

Deputy heads of School

Title: Associate Professor

Name and Surname: Michelle Viljoen

Position: Deputy Director: Pharmacology and Pharmacy Practice

List of Qualifications:  B.Pharm; MSc (Pharmacology); PhD

Telephone: +27 21 959 2641

Fax: +27 21 959 3407

Email: mviljoen@uwc.ac.za

Biography

Michelle obtained her B.Pharm (1993) and MSc (1996) from Potchefstroom University for Christian Higher Education (PU for CHE) and a PhD (2011) in Pharmacology from the North-West University (NWU), South Africa. She worked as a Regulatory Affairs Consultant (1995-2001) and as a hospital ward pharmacist (2001-2002). She was a Pharmacology lecturer and researcher at PU for CHE and NWU from 2002-2017 for Pharmacy and Nursing students. She joined the School of Pharmacy at University of the Western Cape in February 2017.
Her main research focus areas are: pharmacokinetics, pharmacodynamics, pharmacogenetics and more recently pharmacovigilance of antiretrovirals.  Collaborative research activities in the field of infectious diseases and appropriate antimicrobial use and prescribing practises was expanded since joining UWC in 2017. Prof Viljoen supervised and co-supervised more than 10 Master students and currently two PhD students.  She published more than 25 papers in high impact International and National peer reviewed journals and has presented her research at numerous International and National conferences since 2008.  She has a special interest in bioethics and ethics related to health and clinical research and was the Vice-chair of the Human Research Ethics Committee (HREC) of the Faculty of Health Sciences, NWU (2016).
Prof Viljoen has been an external examiner and moderator for undergraduate courses, MSc dissertations and PhD thesis for University of the Witwatersrand, University of KwaZulu-Natal, University of Cape Town, University of Pretoria, UWC and NWU.

She has acted as an evaluator for the National Research Foundation (NRF, project funding and researcher rating) and as a reviewer for numerous manuscripts in journals such as Pharmacological Research; Pharmacogenetics and Genomics; Health SA Gesondheid; British Journal of Clinical Pharmacology; Antiviral Research; AIDS Research and Human Retroviruses; Bioanalysis; Pharmacogenomics and Personalized Medicine; Therapeutics and Clinical Risk Management; Journal of Antimicrobial Chemotherapy and Southern African Journal of HIV Medicine


Committees served on:
 
  • Member of the South African Pharmacy Council (SAPC) since 1993
  • Member of the South African Society for Basic and Clinical Pharmacology (SASBCP) since 2002
  • Member of the African Drug, Metabolism and Development Society: 2007-2009
  • Approved Tutor for pharmacy interns with SAPC. Since 2013
  • Member of the Pharmaceutical Society of South Africa (PSSA) since 2015
  • Member of Human Research Ethics Committee (HREC) at North West University (NWU): 2013 – 2016
  • Vice Chair of HREC at NWU: January 2016 – December 2016
  • Research Committee member of the District Kenneth Kaunda (DKK) in the North West Province: 2014 – 2016
  • Member of the Inter-professional Education Committee (Faculty of Health Sciences, NWU), secundos for School of Pharmacy: April 2014 – December 2016
  • Community Engagement Committee – Faculty of Health Sciences (NWU): Aug 2014 – Sept 2016
  • Member of Research Ethics Committee Association of Southern Africa (REASA) since 2016-2019
  • Senate member of University of Western Cape (UWC) –since 2017
  • Member of the Biomedical Research Ethics Committee (BMREC) at the University of Western Cape (UWC) – since 2018


Recent Publications:

1. van Graan R, Viljoen M, Rheeders M, Motara F. Retrospective clinical analysis of adverse drug reactions associated with antiretroviral therapy in the Tlokwe district, South Africa. S Afr Fam Pract. 2018, 60(1): 31-36.

2. Greffrath WP, du Plessis JM, Viljoen M, Cockeran M. Hypertriglyceridaemia and the risk of pancreatitis and atherosclerosis 6 months post LPV/r initiation. S Afr J HIV Med. 2018, 19(1):a766.

3. Dalwadi D, Ozuna L, Harvey BH, Viljoen M, Schetz JA. Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs. Pharmacological Reviews 2018, 70:684-711.

4. Muntingh GL, Viljoen M. ERROR 4:04 – Sleep not found. S Afr Fam Pract. 2018; 60(3): 33-39.

5. Muntingh GL, Viljoen M. A “site for sore eyes. S Afr Fam Pract. 2018; 60(6): 7-11.

6. Reitsma GM, Scrooby B, Rabie T, Viljoen M,  Smit K,  du Preez A, Pretorius R, van Oort A, Swanepoel M, Naude A, Dolman R. Health students’ experiences of the process of interprofessional education: a pilot project. Accepted for publication Jan 2019.  Journal of Interprofessional Care. DOI: 10.1080/13561820.2019.1572600.

7. Ellis C, Kruger HS, Ukegbu P, Kruger IM, Viljoen M, Kruger MC. Differences between bone mineral density, lean and fat mass of HIV positive and HIV negative black woman. Published online 28 May 2019. Journal of Endocrinology, Metabolism and Diabetes of South Africa (JEMDSA).  DOI: 10.1080/16089677.2019.1589047.

8. Rudman C, Rheeders M, Viljoen M. A retrospective investigation of adult patients receiving third-line antiretroviral therapy in the North West province, South Africa. African Health Sciences. 2020; 20(2): 549- 559. https://doi.org/10.4314/ahs.v20i2.2

9. Ellis C, Kruger HS, Viljoen M, Dave JA, Kruger MC. Factors associated with bone mineral density and bone resorption in postmenopausal HIV-infected women on antiretroviral therapy: a prospective cohort study. Nutrients, 2021;13,2090. https://doi.org/10.3390/nu13062090.

10. Pillay S, Mulubwa M, Viljoen M. Parental reporting of adverse drug reactions in South Africa: An online survey. African Journal of Primary Health Care & Family Medicines, 2021;13(1),a2880. https://doi.org/10.4102/ phcfm.v13i1.2880.

11. Viljoen M, Coetzee R, Hoffman N, McCartney J, Upton E, van Huyssteen M. 2021. Reflection on remote teaching and learning of a final year BPharm clinical training module during a pandemic. Accepted for publication 21 April 2021 – African Journal of Health Professions Education.

12. Moustafa I, Saka S, Viljoen M, Oosthuizen F. Vitamin E and levocarnitine as prophylaxis against doxorubicin-induced cardio toxicity in the adult cancer patient: A review. Journal of Oncology Pharmacy Practice, 2022:1-12 DOI: 10.1177/10781552221078284

13. Viljoen M, Muntingh GL. Adverse drug reactions: To report, or not to report? South African General Practitioner, 2022;3(2):22-25. https://doi.org/10.36303/SAGP.2022.3.2.0118

14. Moustafa I, Viljoen M, Perumal-Pillay VA, Oosthuizen F. Critical appraisal of clinical
guidelines for prevention and management of doxorubicin-induced cardiotoxicity. Journal of Oncology Pharmacy Practice, 2022:1-14 DOI: 10.1177/10781552221147660

Title:Associate professor

Name and Surname: Denzil R. Beukes

Position:  Deputy director and associate professor of Pharmaceutical Chemistry

List of Qualifications: BSc, BSc Hons, PhD

Telephone: 021-959 2352

Fax: 021 9591588

Email: dbeukes@uwc.ac.za

Biography

Professor Beukes obtained his BSc and BSc Hons degrees majoring in Chemistry and Biochemistry at Rhodes University.  After a two-year stint in the pharmaceutical industry he returned to Rhodes University to pursue an MSc degree which was upgraded to a PhD.  He was a visiting researcher at the Scripps Institution of Oceanography, University of California, San Diego and the College of Pharmacy, Oregon State University.  
Since 1999, Professor Beukes has been teaching courses in Pharmaceutical Organic Chemistry, Medicinal Chemistry, Natural Products Chemistry, Pharmaceutical Analysis and Spectroscopy, Pharmaceutical Inorganic Chemistry and Pharmaceutical Biochemistry.
His main research interest is in the discovery of biological active natural products with a focus on cancer and infectious diseases.  He uses advanced spectroscopic tools and synthetic chemistry for the structural characterization and pharmacological exploration of bioactive natural products.  Current research is focused on natural products from marine organisms, plants and microorganisms.  
He has supervised more than 30 masters and doctoral theses, and published numerous papers in international, peer-reviewed journals, acted as external examiner for undergraduate programmes and postgraduate theses from both local and international universities.  In addition, he regularly acts as reviewer for local and international journals (e.g. Marine Drugs, European Journal of Medicinal Chemistry, Phytochemistry, etc.) and evaluate funding and rating applications for the National Research Foundation and the South African Medical Research Council (SAMRC).
 
Committees served on:
  • Member, Science Faculty Higher Degrees Committee (UWC) (2015-2020)
  • Member, Ethical Standards Committee (RU)- (2010-2013)
  • Appointments committee (Rhodes University) for various academic and technical posts
  • Member, South African Chemical Institute, Western Cape Section committee
  • Member, National Research Foundation rating and grant panels
  • Member, Department of Science and Innovation (DSI)
  • Member, South African Pharmacy Council (SAPC) delegation for accreditation/inspection visits to various South African Pharmacy Schools

Recent Publications:

Acquah, K.S.; Beukes, D.R.; Warner, D.F.; Meyers, P.R.; Sunassee, S.N.; Maglangit, F.; Deng, H.; Jaspars, M.; Gammon, D.W. Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners. Molecules 2020, 25, 2979.

Lerata, M.S.; D’Souza, S.; Sibuyi, N.R.; Dube, A.; Meyer, M.; Samaai, T.; Antunes, E.M.; Beukes, D.R. Encapsulation of Variabilin in Stearic Acid Solid Lipid Nanoparticles Enhances Its Anticancer Activity in Vitro. Molecules 2020, 25, 830.

Nyambe MN, Koekemoer TC, van de Venter M, Goosen ED, Beukes DR. In Vitro Evaluation of the Phytopharmacological Potential of Sargassum incisifolium for the Treatment of Inflammatory Bowel Diseases. Medicines (Basel). 2019, 6(2), 49. doi:10.3390/medicines6020049 

Munedzimwe TC, van Zyl RL, Heslop DC, Edkins AL, Beukes DR. Semi-Synthesis and Evaluation of Sargahydroquinoic Acid Derivatives as Potential Antimalarial Agents. Medicines (Basel). 2019, 6(2), 47. doi:10.3390/medicines6020047 

Mutenta N. Nyambe, Denzil R. Beukes, Maryna Van De Venter, Bresler Swanepoel & Buyiswa G. Hlangothi. Isolation and characterisation of altissimin: a novel cytotoxic flavonoid C-apioglucoside from Drimia altissima (Asparagaceae), Natural Product Research, 2019, DOI: 10.1080/14786419.2019.1596097

Davies-Coleman, Michael T., Antunes, Edith M., Beukes, Denzil R., & Samaai, Toufiek. Colourful chemistry of South African latrunculid sponges. South African Journal of Science, 2019, 115(5-6), 1-7. https://dx.doi.org/10.17159/sajs.2019/5534 

Knott, M.G.; de la Mare, J.; Edkins, A.L.; Zhang, A.; Stillman, M.J.; Bolton, J.J.; Antunes, E.M.; Beukes, D.R.; Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum. Phytochemistry Letters 2019, 29,182-185

Staff

Title:  Professor
Name and Surname: Angeni Bheekie
Position:  Associate Professor: Experiential learning 
List of Qualifications: B.Sc (Dublin), B.Pharm (Durban-Westville), M.Pharm & PhD (University of the Western Cape)
Telephone: 021-959 2977 or 3666
Fax: 021-9593407
Email: abheekie@uwc.ac.za

Biography

Angeni Bheekie obtained her PhD (2001) and from the University of the Western Cape (UWC). She is registered with the South African Pharmacy Council as a pharmacist and tutor.  After practicing in hospital pharmacy in the public and private health care sectors, she embarked on postgraduate study at UWC (1994). Her research interests include service learning, community engagement, chronic disease management and implementation research at the primary care level. 
Committees served on:
Board Member Touching Nations (Not-for profit organisation)


Publications: 
Van Huyssteen M & Bheekie A. (2017).The hidden curriculum of work-based learning for pharmacy students in public sector pharmacies in South Africa. Pharmacy Education, 17(1): 190-198. 

Bheekie A & van Huyssteen M (2017). An assessment of social accountability among South African pharmacy schools from public domain information. African Journal of Physical Activity and Health Sciences October (Suppl 1:2): 317-334.

Bheekie A, Van Huyssteen M, Coetzee R (2019). Exploring the implications of needs based pharmacy education modelled on population health: perspective from a developing country. Pharmacy 7(3), 116; https://doi.org/10.3390/pharmacy7030116

van Huyssteen M and Bheekie A. (2019). Exploring practising pharmacy graduates’ views on improving the effectiveness of pharmacy education at the University of the Western Cape, South Africa. African Journal of Health Professions Education, 11(3), pp.77-80. doi.org/10.7196/AJHPE.2019.v11i3.1065 

Van Huyssteen M, Bheekie A, Srinivas S, Essack A (2020). Continuous professional development for public sector pharmacists of South Africa: a case study of mapping competencies in a pharmacists’ preceptor programme. Pharmacy MDPI 8 (96): https://doi. 10.3390/pharmacy8020096

Heyns, J., van Huyssteen, M., & Bheekie, A. (2021). The effectiveness of using text and pictograms on oral rehydration, dry-mixture sachet labels. African Journal of Primary Health Care & Family Medicine, 13(1), 11 pages. doi:https://doi.org/10.4102/phcfm.v13i1.2646

Title:  Professor

Name and Surname: Jacques Joubert

Position:  Associate Professor

List of Qualifications: PhD, MSc, B.Pharm.

Telephone: 021 959 2195

Email: jjoubert@uwc.ac.za

Biography

I obtained my B.Pharm (2005), M.Sc. (2007) and Ph.D. (2012) in Pharmaceutical Chemistry focused on drug design and discovery from the North-West University, South Africa (SA). In 2009 I was appointed at the University of the Western Cape (UWC), SA as a Lecturer in Pharmaceutical Chemistry, School of Pharmacy. In January 2013, I was promoted to Senior Lecturer and currently hold the position of Associate Professor (promoted in 2016). My research is focused on the design and evaluation of novel agents for neurodegenerative disorders such as; Alzheimers- and Parkinson's disease, and infectious diseases such as; tuberculosis and malaria. These studies entail organic synthesis and structural elucidation, molecular modelling, biological evaluations, and biological assay design and validation. 

I am a member of the Pharmaceutical Society of SA and the Academy of the Pharmaceutical Society of SA (APSSA). Currently, I am an active reviewer of research papers submitted for publication to the following high impact (JIF: 2.5 - 5) international journals namely; J Med Chem, Molecules, European Journal of Medicinal Chemistry, Future Medicinal Chemistry, MedChemComm, ChemMedChem, Future Medicinal Chemistry, Bioorganic and Medicinal Chemistry, Tetrahedron Letters, Expert Opinion on Therapeutic Patents and Bioorganic and Medicinal Chemistry Letters.

I have received numerous awards and acknowledgements for excellence in research. In 2009 I was awarded the 1st prize for the best presentation at the iThemba Pharmaceuticals Symposium and in 2012 I was awarded both the 'APSSA National Distinguished Pharmacy Teacher' and 'APSSA Best National Publication in Pharmaceutical Chemistry' awards. In 2013, 2015, 2016, 2018 and 2019 my research group again won the ‘APSSA Best National Publication in Pharmaceutical Chemistry' award. Two of my post-graduate students have been awarded the 1st prize for the top APSSA Young Scientist in pharmaceutical sciences research in 2015 and 2018. I was also awarded the following research grants; NRF Thuthuka (2013-2015), NRF Post-Graduate Training (2017-2018) and NRF Competitive Rated Researcher (2017-2019) grants. In 2019 I received a NRF C-rating. In 2021 I was awarded a R50 000 research prize for the best undergraduate paper at UWC, Faculty of Natural Sciences. 
I have also been appointed (2013 - current) by the Department of Health of South Africa to the Pharmaceutical and Analytical Committee (P&A) of the Medicines Control Council of South Africa (MCC, now SAHPRA). I was appointed to this Committee because of my research expertise in drug design and development and my ability to scrutinize research reports and comment on the quality of new medicine. In my tenure, I have authored more than 150 pharmaceutical quality evaluation reports and peer reviewed countless reports on new chemical entities and generic products for registration in South Africa. My connection with the MCC has also led to my international involvement in the European Medicine Authority Article 58 task team (2017-2018). Article 58 is aimed at making high-priority medicine.

Committees served on:
  • Pharmaceutical and Analytical Committee (P&A) of the Medicines Control Council of South Africa (MCC, now SAHPRA) (2013-current)
  • European Medicine Authority Article 58 task team (2017-2018)
  • South African Pharmacy Council as a Curriculum Committee.Member to evaluate the New Pharmacy Curriculum of the 7 Pharmacy Schools in RSA (Specialist in Pharmaceutical Chemistry, 2013 - 2014).

Recent Publications:
Joubert, Jacques; Foka, Germaine B; Repsold, Benjamin P; Oliver, Douglas W; Kapp, Erika; Malan, Sarel F; ,Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease,European journal of medicinal chemistry,125,,853-864,2017,Elsevier Masson

Teponnou, Gerard AK; Joubert, Jacques; Malan, Sarel F; ,"Tacrine, Trolox and tryptoline as lead compounds for the design and synthesis of multi-target agents for Alzheimer’s disease therapy",The open medicinal chemistry journal,11,,24,2017,Bentham Science Publishers

Kapp, Erika; Visser, Hanri; Sampson, Samantha L; Malan, Sarel F; Streicher, Elizabeth M; Foka, Germaine B; Warner, Digby F; Omoruyi, Sylvester I; Enogieru, Adaze B; Ekpo, Okobi E; ,"Versatility of 7-substituted coumarin molecules as antimycobacterial agents, neuronal enzyme inhibitors and neuroprotective agents",Molecules,22,10,1644,2017,Multidisciplinary Digital Publishing Institute

Kapp, Erika; Malan, Sarel F; Joubert, Jacques; Sampson, Samantha L; ,Small molecule efflux pump inhibitors in Mycobacterium tuberculosis: a rational drug design perspective,Mini reviews in medicinal chemistry,18,1,72-86,2018,Bentham Science Publishers

Denya, Ireen; Malan, Sarel F; Enogieru, Adaze B; Omoruyi, Sylvester I; Ekpo, Okobi E; Kapp, Erika; Zindo, Frank T; Joubert, Jacques; ,"Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease",Medchemcomm,9,2,357-370,2018,Royal Society of Chemistry

Sharma, Rajan; Joubert, Jacques; Malan, Sarel F; ,Synthesis and biological evaluations of NO-donating oxa-and aza-pentacycloundecane derivatives as potential neuroprotective candidates,Molecules,23,2,308,2018,Multidisciplinary Digital Publishing Institute

Repsold, BP; Malan, Sarel F; Joubert, Jacques; Oliver, DW; ,Multi-targeted directed ligands for Alzheimer’s disease: design of novel lead coumarin conjugates,SAR and QSAR in Environmental Research,29,3,231-255,2018,Taylor & Francis

Yvette, Opute M; Malan, Sarel F; Taylor, Dale; Kapp, Erika; Joubert, Jacques; ,Adamantane amine-linked chloroquinoline derivatives as chloroquine resistance modulating agents in Plasmodium falciparum,Bioorganic & medicinal chemistry letters,28,8,1287-1291,2018,Pergamon

Sharma, Rajan; Joubert, Jacques; Malan, Sarel F; ,Recent developments in drug design of NO-donor hybrid compounds,Mini reviews in medicinal chemistry,18,14,1175-1198,2018,Bentham Science Publishers

Denya, Ireen; Malan, Sarel F; Joubert, Jacques; ,Indazole derivatives and their therapeutic applications: a patent review (2013-2017),Expert opinion on therapeutic patents,28,6,441-453,2018,Taylor & Francis

Joubert, Jacques; Foxen, Eugene B; Malan, Sarel F; ,Microwave Optimized Synthesis of N-(adamantan-1-yl)-4-[(adamantan-1-yl)-sulfamoyl] benzamide and Its Derivatives for Anti-Dengue Virus Activity,Molecules,23,7,1678,2018,Multidisciplinary Digital Publishing Institute

Joubert, Jacques; ,Bicyclic bis-heteroaryl derivatives as inhibitors of the α-synuclein protein: a patent evaluation of WO2018138088A1,Expert opinion on therapeutic patents,28,12,939-945,2018,Taylor & Francis

Zindo, Frank T; Malan, Sarel F; Omoruyi, Sylvester I; Enogieru, Adaze B; Ekpo, Okobi E; Joubert, Jacques; ,"Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents",European journal of medicinal chemistry,163,,83-94,2019,Elsevier Masson

Cloete, Ruben; Kapp, Erika; Joubert, Jacques; Christoffels, Alan; Malan, Sarel F; ,Molecular modelling and simulation studies of the Mycobacterium tuberculosis multidrug efflux pump protein Rv1258c,PloS one,13,11,e0207605,2018,"Public Library of Science San Francisco, CA USA"

Joubert, Jacques; ,"Synthesis, crystal structure, DFT studies, docking studies, and fluorescent properties of 2-(adamantan-1-yl)-2H-isoindole-1-carbonitrile",Crystals,9,1,24,2019,Multidisciplinary Digital Publishing Institute

Joubert, Jacques; Strydom, Natasha; Geldenhuys, Werner J; Greyling, Yolande; V Dyk, Sandra; Malan, Sarel F; ,Hexacyclododecylamines with Sigma-1 receptor affinity and calcium channel modulating ability,The Open Medicinal Chemistry Journal,13,1,,2019,

Denya, Ireen; Malan, Sarel F.; Joubert, J; ,Multifunctional Monoamine Oxidase and Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease.,"Pharmaceutical Biocatalysis: Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases",4,,427,2019,462

Joubert, Jacques; ,Crystal structure of N-(adamantan-1-yl)-5-(dimethylamino)naphthalene-1-sulfonamide,Zeitschrift für Kristallographie - New Crystal Structures,,,,2019,

Ndzibongwana, Sethu; Ngobese, Samukelo; Sayed, Ahmad; Shongwe, Ciniso; White-Phillips, Simon; Joubert, Jacques; ,"Structural analysis, molecular modelling and preliminary competition binding studies of AM-DAN as a NMDA receptor PCP-site fluorescent ligand",Molecules,24,22,4092,2019,Multidisciplinary Digital Publishing Institute

Joubert, Jacques; Foka, Germaine B; ,"Crystal structure of 7-(2-{4-[(4-bromophenyl) methyl] piperazin-1-yl} ethoxy)-2H-chromen-2-one, C22H23BrN2O3",Zeitschrift für Kristallographie-New Crystal Structures,235,2,437-439,2020,De Gruyter

Al-Wahaibi, Lamya H; Joubert, Jacques; Blacque, Olivier; Al-Shaalan, Nora H; El-Emam, Ali A; ,"Crystal structure, Hirshfeld surface analysis and DFT studies of 5-(adamantan-1-yl)-3-[(4-chlorobenzyl) sulfanyl]-4-methyl-4 H-1, 2, 4-triazole, a potential 11β-HSD1 inhibitor",Scientific reports,9,1,1-11,2019,Nature Publishing Group

Joubert, Jacques; Kapp, Erika; ,Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening,Bioorganic & medicinal chemistry letters,30,9,127075,2020,Pergamon

Sharma, Rajan; Joubert, Jacques; Su, Hong; Caira, Mino R; Malan, Sarel F; ,"Synthesis, crystal structure, DFT studies and biological evaluation of N-benzamido derivatives of oxahexacycloundecyl amines: A case of enantiomerism leading to molecular disorder",Journal of Molecular Structure,1215,,128248,2020,Elsevier

Joubert, Jacques; ,Small-molecule inhibitors of α-synuclein for the treatment of Parkinson’s disease: a patent landscape,,,,,2020,"Newlands Press Ltd London, UK"

Egunlusi, Ayodeji O; Malan, Sarel F; Omoruyi, Sylvester I; Ekpo, Okobi E; Palchykov, Vitalii A; Joubert, Jacques; ,Open and rearranged norbornane derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP+-and calcium overload-induced excitotoxicity in neuroblastoma SH-SY5Y cells,European Journal of Medicinal Chemistry,204,,112617,2020,Elsevier Masson

Zondagh, Luke S; Malan, Sarel F; Joubert, Jacques; ,"Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents",Journal of enzyme inhibition and medicinal chemistry,35,1,1596-1605,2020,Taylor & Francis

Egunlusi, Ayodeji O; Malan, Sarel F; Joubert, Jacques; ,"Synthesis of 4-oxatricyclo [5.2. 1.02, 6] dec-8-ene-3, 5-dione derivatives as lead scaffolds for neuroprotective agents",,,,,2020,Arkat USA

Egunlusi, Ayodeji O; Malan, Sarel F; Omoruyi, Sylvester I; Ekpo, Okobi E; Joubert, Jacques; ,"4-Oxatricyclo [5.2. 1.02, 6] dec-8-ene-3, 5-dione Derivatives as NMDA Receptor-and VGCC Blockers with Neuroprotective Potential",Molecules,25,19,4552,2020,Multidisciplinary Digital Publishing Institute.

Sheunopa C. Mzezewa, Sylvester I. Omoruyi, Luke S. Zondagh, Sarel F. Malan, Okobi E. Ekpo, Jacques Joubert. Design, synthesis and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s Disease agents. Journal of enzyme inhibition and medicinal chemistry. Article in press 2021.

Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, and Sarel F. Malan. Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis. Advances in Pharmacological and Pharmaceutical Sciences. Article in press. 2021.

Hemaida, Aya; Hassan, Ghada; Maarouf, Azza; Joubert, Jacques; El-Emam, Ali. Synthesis and Biological Evaluation of Thiazole-Based Derivatives as Potential Acetylcholinesterase Inhibitors". ACS Omega. Article on press. 2021.

Kareem, Afeez I; Malan, Sarel F; Joubert, Jacques; ,Radical Releasing Anti-Tuberculosis Agents and the Treatment of Mycobacterial Tuberculosis Infections-An Overview.,Mini Reviews in Medicinal Chemistry,,,,2021. Article in press. doi: 10.2174/1389557521666210219161045

Title: Professor

Name and Surname: Marique Aucamp

Position:  Associate Professor

List of Qualifications: B.Pharm, MSc (Pharmaceutics), PhD

Telephone: +27 21 9593229

Email: maucamp@uwc.ac.za

Biography

Marique obtained her B.Pharm (2003), MSc. Pharmaceutics, cum laude (2005) from North-West University, Potchefstroom, South Africa.  She started her career as a laboratory manager at the Research Institute for Industrial Pharmacy inc. CENQAM (North-West University (NWU), Potchefstroom), a pharmaceutical quality control laboratory where she obtained extensive experience relating to the pharmaceutical industry and quality requirements for pharmaceutical products.  During this time she was also enrolled as a full-time PhD student at the Unit for Drug Research and Development, NWU.  After obtaining her PhD (2010), she was successful in obtaining a DST/NRF Post-doctoral Fellowship (2010 – 2012).  She was appointed as a senior lecturer in the Centre of Excellence for Pharmaceutical Sciences, North-West University (2013 – 2015) and was promoted to associate professor (2016 – 2017) at the same institution.  In August 2017, she accepted a Senior Lecturer position at the School of Pharmacy, University of the Western Cape (UWC) and was promoted to Associate Professor in 2019.  Marique holds an Y2 rating from the NRF (National Research Foundation). In April 2019, she was awarded a prestigious Royal Society / African Academy of Sciences FLAIR Fellowship.  
Her research focus on the solid-state chemistry of drugs translated to the development of innovative nano- or microparticulate drug delivery systems, addressing key drug delivery and patient treatment challenges.  She is the author of 39 peer reviewed research publications, 3 book chapters and 23 conference proceedings.  She is also the inventor of 3 innovations which resulted in over 15 patent applications. To date she has supervised/co-supervised more than 25 MSc and more than 12 PhD students.

Prof Aucamp has acted as an external examiner and moderator for undergraduate courses, M.Sc. and Ph.D. theses for University of the Witwatersrand, University of Cape Town, University of Limpopo, UWC and NWU. She acts as peer reviewer for several internationally recognised scientific journals such as: AAPS PharmSciTech, AAPS Pharmaceutical Research, International Journal of Pharmaceutics, European Journal of Pharmaceutical Sciences, CrystEngComm, Pharmaceutics and Molecules.  She has also served on several NRF review panel and is an active member of the American Association for Pharmaceutical Sciences (AAPS).


Committees served on:
  • Academy of Pharmaceutical Sciences of South Africa (APSSA) executive committee – Honorary secretary (2018 – 2020).
  • APSSA member (2017 to present).
  • Member of the Spectroscopic Society of South Africa
  • Member of the South African Chapter for the Controlled Release Society
  • University of the Western Cape (UWC) Senate (since 2019)
  • University of the Western Cape (UWC) Animal Ethics Committee (2019 to present)

Recent Publications:
Witika, B.A., Aucamp, M., Mweetwa, L.L., Makoni, P.A.  2021.  Application of fundamental techniques for physico-chemical characterisations to understand post-formulation performance of pharmaceutical nanocrystalline materials.  Crystals., 11(3), doi.org/10.3390/cryst11030310.

Ngilirabanga, J.B., Aucamp, M.E., Rosa, P.C.P., Samsodien, H.  2020.  Mechanochemical synthesis and physicochemical characterization of isoniazid and pyrazinamide co-crystals.  Frontiers in Chemistry, 8: 595908, doi: 10.3389/fchem.2020.595908.

Ngilirabanga, J.B., Rosa, P.P., Aucamp, M., Kippie, Y., Samsodien, H.  2020.  Dual-drug co-crystal synthesis for synergistic in vitro effect of three key first-line antiretroviral drugs. Journal of Drug Delivery Science and Technology, 60:101958,  doi.org/10.1016/j.ddst.2020.101958.

Miller, N., Malherbe, C.J., Gerber, W., Hamman, J.H., Aucamp, M., Joubert, E.  2020.  Physicochemical stability of enriched phenolic fractions of Cyclopia genistoides and ex vivo bi-directional permeability of major xanthones and benzophenones.  Planta Medica, doi: 10.1055/a-1265-1945.

Ndumiso, M., Buchtová, N., Husselman, L., Mohamed, G., Klein, A., Aucamp, M., Canevet, D., D’Souza, S., Maphasa, R.E., Boury, F., Dube, A.  2020.  Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum.  Colloids and Surfaces B: Biointerfaces, 188.

Human, C., De Beer, D., Aucamp, M., Marx, I.J., Malherbe, C., Viljoen-Bloom, M., Van der Rijst, M., Joubert, E.  2020.  Preparation of rooibos extract-chitosan microparticles: Physicochemical characterisation and stability of aspalathin during accelerated storage.  LWT, 108653.

Aucamp, M., Milne, M.  2019.  The physical stability of drugs linked to quality-by-design (QbD) and in-process technology (PAT) perspectives.  European Journal of Pharmaceutical Sciences, 105057.

Aucamp, M., Liebenberg, W., Okaecwe, T., Geldenhuys, M., Stieger, N.  2019.  Compatibility between four anti-TB drugs and tablet excipients determined by microcalorimetry.  Die Pharmazie, 6:350 – 351.

Viljoen, F.P., Du Preez, J.L., Petzer, A., Wessels, J.C., Petzer, J. Aucamp, M.E.  2019.  Development and validation of a HPLC electrochemical detection method to measure COMT activity as a tool in drug development.  Die Pharmazie, 74 (5): 270 – 276.

Viljoen, F.P., du Preez, J.L., Wessels, J.C., Aucamp, M.E., Meyer, L.C.R. and Pohlin, F., 2019. An HPLC-DAD validated method for the detection and quantification of cortisol, corticosterone and melatonin in plasma samples of two different animal species. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 74(4), pp.206-211.

Van Zyl, L., Viljoen, J.M., Haynes, R.K., Aucamp, M., Ngwane, A.H., Du Plessis, J.  2019.  Topical delivery of artemisone, clofazimine and decoquinate encapsulated in vesicles and their in vitro efficacy agains mycobacterium tuberculosis.  AAPS PharmSciTech, 20(1), 33.

Human, C., De Beer, D., Van Der Rijst, M., Aucamp, M., Joubert, E.  2019.  Electrospraying as a suitable method for nanoencapsulation of the hydrophilic bioactive dihydrochalcone aspalathin.  Food Chemistry, 276:467 – 474.

Viljoen, F.P., Du Preez, J.L., Wessels, J.C. and Aucamp, M.E., 2018. HPLC electrochemical detection and quantification of monoamines and their metabolites in rat brain tissue samples. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 73(10), pp.563-569.

Burger, C., Aucamp, M., Du Preez, J., Haynes, R.K., Ngwane, A., Du Plessis, J., Gerber, M.  2018.  Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate.  Pharmaceutical Research, 35(10):186.

Miller, N., De Beer, D., Aucamp, M., Malherbe, C.J., Joubert, E. 2018. Inulin as microencapsulating agent improves physicochemical properties of spray-dried aspalathin-rich green rooibos (Aspalathus linearis) extract with α-glucosidase inhibitory activity. Journal of Functional Foods, 48:400-409.

Neglur, R., Aucamp, M., Liebenberg, W., Hosten, E., Groof, D.  2018.  Water and the relationship to the crystal structure stability of azithromycin: thermal investigations of solvatomorphism, amorphism and polymorphism.  Journal of Thermal Analysis and Calorimetry, 132(1), 373 - 384.

De Beer, D., Pauck, C.E., Aucamp, M., Liebenberg, W., Stieger, N., Van der Rijst, M., Jourbert, E.  2018.  Phenolic and physicochemical stability of a functional beverage powder mixture during storage-effect of the microencapsulant inulin and food ingredients.  Journal of Science of Food and Agriculture, doi:10.1002/jsfa.8787.

Du Preez, J.L., M.E. Aucamp., C. Burger., M. Gerber., J.M. Viljoen., L. van Zyl., J. Du Plessis.  2018.  Development and validation of the simultaneous determination of artemisone, clofazimine and decoquinate with HPLC.  Die Pharmazie, 73 (3) : 139 – 142.

Csongradi, C., Du Plessis, J., Aucamp, M.E., Gerber, M.  2017.  Topical delivery of roxithromycin solid-state forms entrapped in vesicles.  European Journal of Pharmaceutics and Biopharmaceutics, 114:96 - 107.

Katsidzira, R.M., Wessels, A., Aucamp, M.  2016.  A novel RP-HPLC method for the detection and quantification of clarithromycin or spiramycin in bulk drug samples and dosage forms.  International Journal of Pharmacy and Pharmaceutical Sciences, 8(12).

Pauck, C., De Beer, D., Aucamp, M., Liebenberg, W., Stieger, N., Human, C., Joubert, E.  2016.  Inulin suitable as reduced-kilojoule carrier for production of microencapsulated spray-dried green Cyclopia subternata (honeybush) extract.  LWT – Food Science and Technology, 75:631 – 639.

Fox, L., Csongradi, C., Aucamp, M., Du Plessis, J., Gerber, M.  2016.  Treatment modalities for acne.  Molecules, 21(8), 1063.

Neglur, R., Grooff, D., Hosten, E., Aucamp, M.E and Liebenberg, W.  2016.  Approximation based integral versus differential isoconversional approaches to the evaluation of kinetic parameters from thermogravimetry.  Kinetic analysis of the dehydration of a pharmaceutical hydrate.  Journal of Thermal Analysis and Calorimetry, 123 (3), 2599 – 2610.

Milne, M., Liebenberg, W and Aucamp, M.E.  2016.  Different amorphous solid-state forms of roxithromycin: A thermodynamic and morphological study.  International Journal of Pharmaceutics, 498 (1):304-315.

Aucamp, M.E., Csongradi, C., Gerber, M., Du Plessis, J.  2016.  A novel RP-HPLC method for the detection and quantification of roxithromycin in topical delivery studies.  Die Pharmazie, 71:175-176.

Aucamp, M., Milne, M., Liebenberg, W.  2016  Amorphous sulfadoxine: A physical stability and crystallization kinetics study.  AAPS PharmSciTech, 17(5), 1100-1109.

Du Toit, T., Malan, M.M., Lemmer, H.J.R., Gouws, C., Aucamp, M.E., Breytenbach, W.J., Hamman, J.H.  2015.  Combining chemical permeation enhancers for synergistic effects.  European Journal of Drug Metabolism and Pharmacokinetics, 40(1), doi: 10.1007/s13318-015-0280-7.

Milne, M., Liebenberg, W., Aucamp, M.E.  2015.  The stabilization of amorphous zopiclone in an amorphous solid dispersion.  AAPS PharmSciTech, 16(5):1190 – 1202, doi:10.1208/s12249-015-0302-4.

Aucamp, M.E., Odendaal, R., Liebenberg, W., Hamman, J.H.  2015.  Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability.  Drug Development and Industrial Pharmacy, 41(7):1100 – 1108.

Rose, W.E., Otto, D.P., Aucamp, M.E., Miller, Z., De Villiers, M.M.  2014.  Prevention of biofilm formation by methacrylate-based copolymer films loaded with rifampin, clarithromycin, doxycycline alone or in combination. Pharmaceutical research, 32, 61-73.

Strydom, S.J., Otto, D.P., Stieger, N., Aucamp, M.E., Liebenberg, W., De Villiers, M.M.  2014.  Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles.  Powder Technology 256:470-476.

Title: Professor

Name and Surname: Star Khoza 

Position: Associate Professor  

List of Qualifications: BPharm, MSc (Zimbabwe) PhD (Texas) 

Telephone: 021-959-9363

Fax: 021-959-3407

Email: sskhoza@uwc.ac.za 

Biography

Star Khoza obtained a Bachelors of Pharmacy and an MSc in clinical pharmacology from the University of Zimbabwe and a PhD in pharmacy from the University of Texas at Austin. His general research interests are in diabetes, dementia, asthma, cancer and pharmacovigilance. His current projects focus on the pharmacological evaluation of traditional medicinal plants using in vivo and in vitro methods for potential use in diabetes, asthma, and cancer.


Recent Publications:
Selected publications previous 5 years 

Manyarara T, Khoza S, Dube A, Maponga CC. Formulation and characterization of a paediatric nanoemulsion dosage form with modified oral drug delivery system for improved dissolution rate of nevirapine. MRS Advances 2018, 1-17. doi:10.1557/adv.2018.320

Masuka JT, Chipangura P, Nyambayo PP, Stergachis A, Khoza S. A comparison of adverse drug reaction profiles in patients on antiretroviral and antitubercular treatment in Zimbabwe. Clinical Drug Investigation. 2017;38:9-17

Marume A, Matope G, Katsande S, Khoza S, Mutingwende I, Mduluza T, Munodawafa-Taderera T, Ndlala AR. Wound healing properties of selected plants used in ethnoveterinary medicine. Frontiers in Pharmacology 2017; 8, Article 544. Doi: 10.3389/fphar.2017.00544

Marume A, Khoza S, Matope G, Nyakudya TT, Mduluza T, Ndhlala AR. Antioxidant properties, protein binding capacity and mineral content of some plants traditionally used in the management of animal wounds. South African Journal of Botany 2017;111:23-28

Khoza S, Moyo I, Ncube D. Comparative hepatotoxicity of fluconazole, ketoconazole, itraconazole, terbinafine, and griseofulvin in rats. Journal of Toxicology 2017

Mafirakureva N, Dzingirayi B, Postma MJ, van Hulst M, Khoza S. Health-related quality of life (HRQoL) in HIV/AIDS patients on antiretroviral therapy at a tertiary care facility in Zimbabwe. AIDS Care 2016;28(7):904-912

Mangoyi J, Khoza S. Effect of irbesartan on blood glucose levels in a mouse model of type 2 diabetes mellitus. African Journal of Pharmacology and Therapeutics. 2015;4(4):169-174

Masuka J, Khoza S, Chibanda D, Mangezi W and Nhachi CFB.  CYP2D6*17 polymorphism and tardive dyskinesia in black psychotic patients on typical antipsychotics.  African Journal of Pharmacology and Therapeutics. 2015; 4(4):150-155

Suku CK, Hill G, Sabbah G, Darko M, Muthuri G, Edward A, Pandit J, Osakwe AI, Elagbaje C C, Nyambayo P, Khoza S, Alex D, Pal SN. Experiences and lessons from implementing cohort event monitoring programmes for antimalarials in four African countries: Results of a Questionnaire-Based Survey. Drug Safety Journal. 2015; 38:115-1126

Musengi Y, Khoza S, Gadaga L, Mangoyi J. Enhanced hypogylcaemic effects of metformin by valsartan in a diabetic rat model. East and Central African Journal of Pharmaceutical Sciences 2014; 17:82-89  

Mafirakureva N, Khoza S, Chitiyo ME, Postma MJ, van Hulst M.  Incidence and pattern of 12-years of reported transfusion reactions in Zimbabwe: A retrospective analysis. Blood Transfusion 2014; 12:362-7

Title:  Professor

Name and Surname: Pierre Mugabo
 
Position:  Emeritus Professor

List of Qualifications: BSc, MBChB, MMed, PhD

Telephone: 021 9593441/ 082 202 3589

Email:pmugabo@uwc.ac.za

Biography

BSc (Nursing) (1973): National University of Rwanda. 
MBChB (General Medicine) (1981): National University of Rwanda.
PhD (Pharmacology) (1987): University of Ghent, Belgium.
MMed Cardiology (1989): Catholic University of Louvain, Brussels, Belgium.

Research activities: 
Basic (in vivo & in vitro) Cardiovascular Pharmacology, 
Clinical Pharmacology: Pharmacokinetics & Pharmacodynamics of: (a) Anti-tuberculosis drugs in adult patients, (b) Antiretroviral drugs (in premature infants and adults patients),(c) Vancomycin in neonates and in critically ill children.

Supervision of postgraduate students:
16 Masters Students (graduated)
5 PhD Students (graduated)

Committees served on: 
Ethics committee Faculty of Natural Sciences 
School of Pharmacy under and postgraduate research committee 

Recent Publications: 
Peer reviewed, accredited Journals:

Ismaila Raji, Kenechukwu Obikeze and Pierre Mugabo.   Comparison of the acute effects of Tulbaghia violacea William Henry Harvey (Alliaceae) on blood pressure and heart rate of ageing male normotensive Wistar kyoto rats and adult male spontaneously hypertensive rats. Tropical Journal of Pharmaceutical Research November 2016; 15 (11): 1319-1326. 
Available online at http://www.tjpr.org; http://dx.doi.org/10.4314/tjpr.v15i11.17

Pierre Mugabo and Richard Madsen. Detection of drug-induced dyslipidaemia in HIV-positive patients treated with protease inhibitors in a South African district – A retrospective study. Tropical Journal of Pharmaceutical Research January 2017; 16 (1): 239-244. Available online at http://www.tjpr.org; http://dx.doi.org/10.4314/tjpr.v16i1.32

Pierre Mugabo and Richard Madsen. Detection of drug-induced dyslipidaemia in HIV-positive patients treated with protease inhibitors in a South African district – A retrospective study. Tropical Journal of Pharmaceutical Research January 2017; 16 (1): 239-244. Available online at http://www.tjpr.org   http://dx.doi.org/10.4314/tjpr.v16i1.32

Mulubwa M & Mugabo P. Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug – resistant tuberculosis. Biomedical Chromatography (2018). https;//doi.org/10.1002/bmc.4325. pp1-7

Mugabo, P. & Mulubwa, M. Population Pharmacokinetic Modelling of Pyrazinamide and Pyrazinoic Acid in Patients with Multi-Drug Resistant Tuberculosis. European Journal of Drug Metabolism and Pharmacokinetics  (2019). https://doi.org/10.1007/s13318-018-00540-w.  pp 1–12.

Mulubwa,M & Mugabo,P. Sensitive ultra-performance liquid chromatography tandem mass spectrometry method for determination of cycloserine in plasma for pharmacokinetics study. Journal of Chromatographic Science. Journal of Chromatographic Science, 2019, 1–5 doi: 10.1093/chromsci/bmz028

Mwila Mulubwa and Pierre Mugabo. Amount of Cycloserine emanating from terizidone metabolism and relationship with hepatic function in patients with drug-resistant tuberculosis. Drugs in R&D. 2019. https://doi.org/10.1007/s40268-019-00281-4

Mwila Mulubwa and Pierre Mugabo. Steady-state population pharmacokinetics of terizidone and its metabolite cycloserine in patients with drug-resistant tuberculosis. Br J Clin Pharmacol. 2019;1–11. DOI:10.1111/bcp13975

Mulubwa, M., Griesel, H. A., Mugabo, P., Dippenaar, R., & van Wyk, L. (2020). Assessment of Vancomycin Pharmacokinetics and Dose Regimen Optimisation in Preterm Neonates. Drugs in R&D, 20(2), 105–113. https://doi.org/10.1007/s40268-020-00302-7

Mugabo P, Mulubwa M. Ethionamide population pharmacokinetics/ pharmacodynamics and therapeutic implications in South African adult patients with drug-resistant tuberculosis. Brit Jnl Clinical Pharma. 2021;1–8. https://doi.org/10.1111/bcp.14795

Published Conference Proceedings (Last five years):
Pierre Mugabo, Osaretin Christabe Okonji, Richard Madsen. Does HIV- infection affect the time to sputum culture conversion during the treatment of drug-resistant tuberculosis? Presented at the 23rd Annual Congress of the Belgian Society of Internal Medicine, 14–15 December 2018, Dolce La Hulpe, La Hulpe, Belgium. ACTA CLINICA BELGICA. 2018, VOL. 73, NO. S2, 1–80. https://doi.org/10.1080/17843286.2018.1542267

Osaretin Christabel Okonji, Pierre Mugabo. Rifampicin and Isoniazid minimum inhibitory concentrations in patients with drug-resistant tuberculosis. Presented at the 24th Annual Congress of the Belgian Society of Internal Medicine, 13–14 December 2019, Dolce La Hulpe, La Hulpe, Belgium. ACTA CLINICA BELGICA. 2019, VOL. 74, NO. S1, 1–71. https://doi.org/10.1080/17843286.2019.1687975

Pierre Mugabo, Ifeoma Patricia Ezeukwu, Richard Madsen, Danie Theron, Leonie van Zyl. Ethionamide steady state pharmacokinetics in patients with drug resistant tuberculosis. Presented at the 24th Annual Congress of the Belgian Society of Internal Medicine, 13–14 December 2019, Dolce La Hulpe, La Hulpe, Belgium. ACTA CLINICA BELGICA. 2019, VOL. 74, NO. S1, 1–71. https://doi.org/10.1080/17843286.2019.1687975

Other conference presentations (last 5 years):
Onyinye Akunne, Pierre Mugabo and Andrew Argent. Non-compartmental analysis of vancomycin pharmacokinetics in critically ill children. Presented at the 17th European Society for Developmental, Perinatal and Paediatric Pharmacology (ESDPPP) Congress. Basel, Switzerland (28-30 May 2019).

Mwila Mulubwa and Pierre Mugabo. Cycloserine amount emanating from terizidone metabolism in patients with multi-drug resistant tuberculosis. Presented at the 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan (1 – 6 July 2018).

Title:  Professor

Name and Surname:

Position:  Associate Professor

List of Qualifications: BPharm, MPharm (UWC), PhD (UCT)

Telephone: (021) 959 2179

Fax: (021) 959 3407

Email: hsamsodien@uwc.ac.za

Biography

Halima Samsodien is an Assoc. Professor in the Pharmaceutics Discipline at the School of Pharmacy, University of the Western Cape. She is actively involved in the research of physicochemical aspects of active pharmaceutical ingredients (APIs) and excipients for the improved pre-formulation and formulation of medicines. She has a preference for the following disease areas especially in paediatric patients viz. HIV, TB and cancer.  She uses techniques such as co-crystallization in supramolecular chemistry to target resistance, stability and other formulation issues. She also studies sensor technology to ensure stability of medicines and paediatric formulations to improve child health.
 
Samsodien has been actively involved as the principle supervisor of +/- 125 Honours, 11 Masters, 2 PhD and 2 Post-doc students. All of whom completed successfully with many in minimal time. She has been consistently successful in attracting funding for her post-graduate programme with funding from the NRF, SA-MRC and/or UWC to ensure that her research group within the Pharmaceutics discipline maintains its research momentum.
She has published 14 peer-reviewed papers to-date culminating from her supervision with Honours, Masters PhD and Postdoc students.   
She is currently the Dean of Research in the Faculty of Science. This is a challenging role in which she is fully committed to applying herself within the position by focusing on the people she has to communicate with to fulfil her role.  She is  a member of the University Research Task Team and a member of the Senate Scholarships and Fellowships Committee (SSFC) as well. Her role as Deputy Dean has engaged her in significant research discussions where she contributes in meaningful ways both by conversation and action. 
 
Previously she was the chair of the School of Pharmacy Postgraduate Committee and the departmental representative at the Science Faculty Higher Degrees Committee for two terms. She was the Head of the Pharmaceutics Discipline for two years and a representative at the UWC Science Faculty Animal Research Ethics Committee (AREC) for two terms. These are all testament to her leadership skills. She is committed to empowering herself and those around her and her research is constantly growing and improving to assist the health needs of people both nationally and internationally.
 
She collaborates actively with other pharmaceutical scientists locally as well as internationally. She has a strong collaboration with Prof Paulo Rosa from the University of Campinas (Sao Paulo, Brazil) in a student/staff exchange programme since 2015. One of her goals is to cement this collaboration as a permanent exchange programme with UWC.  Prof Rosa and Prof Samsodien have each visited SA and Brazil, respectively. They have conducted collaborative research, hosted seminars, had student exchange program and publications.


Recent Publications:

Ngilirabanga, J. B., Rosa, P. P., Aucamp, M., Kippie, Y., & Samsodien, H*. (2020). Dual-drug co-crystal synthesis for synergistic in vitro effect of three key first-line antiretroviral drugs. Journal of Drug Delivery Science and Technology, 60, 101958.
 
Mechanochemical synthesis and physicochemical characterization of isoniazid and pyrazinamide co-crystals
Jean Baptiste Ngilirabanga, Marique Elizabeth Aucamp, Paulo Cesar Pires Rosa and Halima Samsodien*.
Original Research, Front. Chem.  Medicinal and Pharmaceutical Chemistry. October 2020
 
Pharmaceutical Co-crystal: An alternative strategy for enhanced physicochemical properties and drug       synergy. Jean Baptiste Ngilirabanga and Halima Samsodien*.Review. 2021. Nano Select 2021;1–15.
 
4-in-1 multipurpose excipient from Musa acuminata fruit by alkaline-steeping/retrogradation (ASR)
in acetaminophen tablet formulation. Musa Autamashih, Naushaad Ebrahim, Samuel Egieyeh, Marique Aucamp, Paulo Cesar Pires Rosa, Madan S. Poka, Jean Baptiste Ngilirabanga and Halima Samsodien. Molecular Nutrition & Food Research. May 2021.
 
Mechanochemical synthesis and characterization of Zidovudine-lamivudine solid dispersion (binary eutectic mixture). Jean Baptiste Ngilirabanga, Marique Aucamp and Halima Samsodien. Journal of Drug Delivery Science and Technology. June 2021.

Title:  Professor

Name and Surname: Admire Dube 

Position:  Associate Professor

List of Qualifications: B. Pharm (Hons)., M. Pharm., PhD

Telephone: 0219599253

Email: adube@uwc.ac.za

Biography

Involved in learning and teaching of pharmaceutical science at an undergraduate and postgraduate level. Research focuses on nanoscience and nanomedicine, specifically the development of nanoparticle systems for the treatment of infectious diseases.

Committees served on:

Faculty of Natural Sciences Teaching and Learning Committee and Senate Teaching and Learning Committee
Faculty of Natural Sciences Assessment Committee and Senate Assessment Committee.
Faculty of Natural Sciences Academic Planning Committee and Senate Academic Planning
Faculty of Natural Sciences Student Affairs Committee
Faculty of Natural Sciences Professorial Appointments and Promotions Committee
Faculty of Natural Sciences Higher Degrees Committee
School of Pharmacy Disciplinary Committee
Faculty Board (Faculty of Natural Sciences)

Publications:
  1. Rubaka, C., Gathirwa, J.W., Malebo, H.M., Swai, H., Sibuyi, N.R.S., Hilonga, A.,  Dube, A., 2023. Chitosan-coated liposomes of Carrisa spinarum extract: synthesis, analysis and anti-pneumococcal potency. Bioinspired, Biomimetic and Nanobiomaterials, p. 1-12.
  2. Ncube BM., Dube A., Ward K., 2023. The domestication of the African Union model law on medical products regulation: Perceived benefits, enabling factors, and challenges. Frontiers in Medicine. 10.
  3. Louw, E.V., Liebenberg, W., Willers, C., Dube, A., Aucamp, M.E. and Gerber, M., 2022. Comparative study on the topical and transdermal delivery of diclofenac incorporated in nano-emulsions, nano-emulgels, and a colloidal suspension. Drug Delivery and Translational Research, p.1-18.
  4. Dlozi, P.N., Gladchuk, A., Crutchley, R.D., Keuler, N., Coetzee, R. and Dube, A., 2022. Cathelicidins and defensins antimicrobial host defense peptides in the treatment of TB and HIV: Pharmacogenomic and nanomedicine approaches towards improved therapeutic outcomes. Biomedicine & Pharmacotherapy, 151, p.113189.
  5. D'Souza, S., Du Plessis, S.M., Egieyeh, S., Bekale, R.B., Maphasa, R.E., Irabin, A.F., Sampson, S.L. and Dube, A., 2022. Physicochemical and biological evaluation of curdlan-poly (lactic-co-glycolic acid) nanoparticles as a host-directed therapy against Mycobacterium tuberculosis. Journal of Pharmaceutical Sciences, 111(2), pp.469-478.
  6. Madiehe, A.M., Moabelo, K.L., Modise, K., Sibuyi, N.R., Meyer, S., Dube, A., Onani, M.O. and Meyer, M., 2022. Catalytic reduction of 4-nitrophenol and methylene blue by biogenic gold nanoparticles synthesized using Carpobrotus edulis fruit (sour fig) extract. Nanomaterials and Nanotechnology, 12, p.18479804221108254.
  7. Khoza, L.J., Kumar, P., Dube, A., Demana, P.H. and Choonara, Y.E., 2022. Insights into innovative therapeutics for drug-resistant tuberculosis: Host-directed therapy and autophagy inducing modified nanoparticles. International Journal of Pharmaceutics, 622, p.121893.
  8. Shabangu, P.P., Kuwana, R.J. and Dube, A., Collaborative Reliance in Medicine Safety and Quality Regulation: Investigation of experiences in handling N-nitrosamine impurities among ZaZiBoNa Participating Countries. Frontiers in Medicine, p.2713.
  9. Dube, A., Semete-Makokotlela, B., Ramalapa, B., Reynolds, J. and Boury, F., 2021. Nanomedicines for the treatment of infectious diseases: Formulation, delivery and commercialization aspects. In Green Synthesis in Nanomedicine and Human Health (pp. 271-290). CRC Press.
  10. Mansor, M.H., Garcion, E., Ramalapa, B., Buchtova, N., Toullec, C., Aucamp, M., Le Bideau, J., Hindré, F., Dube, A., Alvarez-Lorenzo, C. and Galleni, M., 2021. Polymer-Based Protein Delivery Systems for Loco-Regional Administration. In Green Synthesis in Nanomedicine and Human Health (pp. 249-270). CRC Press.
  11. Ncube, B. M., Dube, A., & Ward, K., 2021. Establishment of the African Medicines Agency: progress, challenges and regulatory readiness. Journal of Pharmaceutical Policy and Practice, 14(1), 1-12.
  12. Ncube, B.M., Dube, A. and Ward, K., 2022. Medicines Regulatory Science Expertise in Africa: Workforce Capacity Development and Harmonisation Activities Towards the Establishment of the African Medicines Agency. Pharmaceutical Medicine, 36(2), pp.83-97.
  13. Dube, A., Egieyeh, S. and Balogun, M., 2021. A Perspective on Nanotechnology and COVID-19 Vaccine Research and Production in South Africa. Viruses, 13(10), p.2095.
  14. Mhambi, S., Fisher, D., Tchokonte, M.B.T. and Dube, A., 2021. Permeation Challenges of Drugs for Treatment of Neurological Tuberculosis and HIV and the Application of Magneto-Electric Nanoparticle Drug Delivery Systems. Pharmaceutics, 13(9), p.1479.
  15. Ramburrun, P., Pringle, N. A., Dube, A., Adam, R. Z., D'Souza, S., Aucamp, M. (2021). Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications". Materials, 14(12), 3167.
  16. Maphasa, R.E., Meyer, M. and Dube, A., 2021. The macrophage response to Mycobacterium tuberculosis and opportunities for autophagy inducing nanomedicines for tuberculosis therapy. Frontiers in Cellular and Infection Microbiology, 10, p.618414.
  17. Toullec C, Le Bideau J, Geoffroy V, Halgand B, Buchtova N, Molina-Peña R, Garcion E, Avril S, Sindji L, Dube A, Boury F. Curdlan–chitosan electrospun fibers as potential scaffolds for bone regeneration. Polymers. 2021 Jan;13(4):526.
  18. Heo J, Sobiech TA, Kutscher HL, Chaves L, Sukumaran DK, Karki S, Dube A, Prasad PN, Reynolds JL. Hybrid Curdlan Poly (γ‐Glutamic Acid) Nanoassembly for Immune Modulation in Macrophage. Macromolecular Bioscience. 2021 Jan;21(1):2000358.
  19. Ndumiso, M., Buchtová, N., Husselmann, L., Mohamed, G., Klein, A., Aucamp, M., Canevet, D., D’Souza, S., Maphasa, R.E., Boury, F., Dube, A.  (2020). Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum. Colloids and Surfaces B: Biointerfaces, 188,110816.
  20. Lerata, M.S., D’Souza, S., Sibuyi, N.R., Dube, A., Meyer, M., Samaai, T., Antunes, E.M. and Beukes, D.R., 2020. Encapsulation of variabilin in stearic acid solid lipid nanoparticles enhances its anticancer activity in vitro. Molecules, 25(4), p.830.
  21. Tshweu, L.L., Shemis, M.A., Abdelghany, A., Gouda, A., Pilcher, L.A., Sibuyi, N.R., Meyer, M., Dube, A. and Balogun, M.O., 2020. Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin. RSC Advances, 10(34), pp.19770-19780.
  22. Sibuyi, N.R.S., Moabelo, K.L., Meyer, M. Onani, M.O., Dube, A., Madiehe, A.M. (2019). Nanotechnology advances towards development of targeted-treatment for obesity. Journal of Nanobiotechnology, 17, 122.
  23. Zhou, D.T., Maponga, C.C., Madhombiro, M., Dube, A., Mano, R., Nyamhunga, A., Machingura, I., Manasa, J., Hakim, J., Chirenje, Z.M. and Mudzviti, T., 2019. Mentored postdoctoral training in Zimbabwe: A report on a successful collaborative effort. Journal of Public Health in Africa, 10(2).
  24. Samkange, T. , D'Souza, S. , Obikeze, K. and Dube, A. (2019). Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin. Journal of Pharmacy and Pharmacology, 71: 1497-1507.
  25. Omarch,G., Kippie, Y., Mentor,S., Ebrahim,N., Fisher, D., Murilla,G., Swai, H., Dube, A. (2019). Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 1428-1436,
  26. Sibuyi, N.R.S., Moabelo, K.L., Meyer, M., Onani, M.O., Dube, A. and Madiehe, A.M., 2019. Nanotechnology advances towards development of targeted-treatment for obesity. Journal of Nanobiotechnology, 17(1), pp.1-21.
  27. Sousa, C., Gouveia, L.F., Kreutzer, B., Silva-Lima, B., Maphasa, R.E., Dube, A and Videira, M. (2019). Polymeric Micellar Formulation Enhances Antimicrobial and Anticancer Properties of Salinomycin. Pharmaceutical Research 36(6): 83.
  28. Dube, A. Nanomedicines for infectious diseases. Pharmaceutical Research 36(4): 63.
  29. Ward, K., Suleiman, R., Kippie, Y., Dube, A. A post-market quality assessment of first-line, fixed dose combination antiretrovirals in South Africa. Journal of Applied Pharmaceutical Sciences 9 (2): 97-104.
  30. Bekale, R.B., Du Plessis, S., Hsu, Nai-Jen., Sharma, JR., Sampson, S.L., Jacobs, M., Meyer, M., Morse, G.D., Dube, A. (2018). Mycobacterium Tuberculosis and Interactions with the Host Immune System: Opportunities for Nanoparticle Based Immunotherapeutics and Vaccines. Pharmaceutical Research 36(1): 8.
  31. Tukulula, M., Gouveia, L., Paixao, P., Hayeshi, R., Naicker, B., Dube, A. (2018). Functionalization of PLGA Nanoparticles with 1,3-β-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages. Pharmaceutical Research 35(6): 111.
  32. Manyarara, T. E., Khoza, S., Dube, A., Maponga, C.C (2018). Formulation and characterization of a paediatric nanoemulsion dosage form with modified oral drug delivery system for improved dissolution rate of nevirapine. MRS Advances: 1-17.

Title: Dr

Name and Surname:  Erika Kapp

Position:  Lecturer Pharmaceutical Chemistry

List of Qualifications:  B.Pharm; MSc; PhD

Telephone:  021 959 2193

Email:  ekapp@uwc.ac.za

Biography:

I am a Senior Lecturer and Pharmacist employed in the School of Pharmacy at the University of the Western Cape. I am the head of department of pharmaceutical chemistry and my current roles include lecturing pharmaceutical chemistry to 3rd and 4th year B.Pharm students as well as conducting research with a particular interest in reversal of drug resistance in Mycobacterium tuberculosis. Other research interests include drug design and evaluation for neurodegenerative diseases, the use of polycyclic compounds as treatment in various infectious diseases, and drug metabolism. I obtained my B-Pharm degree (2002) and MSc degree (Pharmaceutical Chemistry, 2005) from North-West University, Potchefstroom campus and PhD (Pharmaceutical Sciences, 2023) from the University of the Western Cape. Apart from my work in the academic sector I have experience in retail pharmacy, hospital pharmacy, the public health care sector, health systems strengthening and training of health care professionals and pharmacy support personnel. I have a passion for education at both undergraduate and postgraduate level as well as research. I have ample experience in training and mentoring of a wide range of health care professionals and am qualified as a facilitator, assessor and moderator. I am registered as a tutor for Pharmacist Interns at the South African Pharmacy Council and currently tutor a number of postgraduate students who are completing their academic internship. I respect knowledge and competence and value good work ethic.

Committees served on: 
Timetable committee
Strategic planning committee

Recent Publications:
Erika Kapp, Hanri Calitz, Elizabeth M. Streicher et al. Discovery and biological evaluation of an adamantyl-amide derivative with likely MmpL3 inhibitory activity, Tuberculosis, 2023. doi.org/10.1016/j.tube.2023.102350

Kapp E, Joubert J, Sampson SL, et al. Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis. Adv Pharmacol Pharm Sci. 2021. doi:10.1155/2021/5583342

Joubert, J. Kapp, E. Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening. Bioorganic & Medicinal Chemistry Letters 2020. doi.org/ 10.1016/j.bmcl.2020.127075

Cloete, R; Kapp, E; Joubert, J. Christoffels, A; Malan, S.F. Molecular modelling and simulation studies of the Mycobacterium tuberculosis multidrug efflux pump protein Rv1258c. PLOS ONE 2019. doi.org/10.1371/journal.pone.0207605

Opute, Y; Malan, S.F; Taylor, D; Kapp, E; Joubert, J. Adamantane amine-linked chloroquinoline derivatives as chloroquine resistance modulating agents in Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters. 2018. doi: 10.1016/j.bmcl.2018.03.026. Epub 2018 Mar 12.

Denya I, Malan SF, Enogieru AB, et al. Design, synthesis and evaluation of indole derivatives as multifunctional agents against alzheimer's disease. Med Chem Commun. 2018. doi.org/10.1039/c7md00569e

Kapp, E; Joubert, J; Sampson, S.L; Malan, S.F. Small molecule efflux pump inhibitors: A rational drug design perspective. Mini-Reviews in Medicinal Chemistry. January 2018. PubMed: 28494730 DOI: 10.2174/1389557517666170510105506

Kapp E, Visser H, Sampson SL, et al. Versatility of 7-substituted coumarin molecules as antimycobacterial agents, neuronal enzyme inhibitors and neuroprotective agents. Molecules. 2017;22(10):10.3390/molecules22101644.

Joubert, J; Foka, G; Repsold, B.P; Oliver, D.W; Kapp, E; Malan S.F. Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry · September 2016. DOI: 10.1016/j.ejmech.2016.09.041

Fatti, G; Monteith, L; Shaikh, N; Kapp, E; Foster, N; Grimwood, A. A Comparison of Two Task-Shifting Models of Pharmaceutical Care in Antiretroviral Treatment Programs in South Africa, JAIDS Journal of Acquired Immune Deficiency Syndromes 71(4):1, April 2016. DOI: 10.1097/QAI.0000000000000912

Joubert, J; Kapp, E. Taylor, D; Smith, P; Malan, S.F. Polycyclic amines as chloroquine resistance modulating agents in Plasmodium falciparum. Bioorganic & medicinal chemistry letters 26(4), January 2016. DOI: 10.1016/j.bmcl.2016.01.052
 

Title:  Prof

Name and Surname: Kim Ward

Position:  Associate Professor in Pharmacy Practice, Discipline Head

List of Qualifications: BPharm, MPharm, PhD (UWC)

Telephone: 021-959 3440

Email: kward@uwc.ac.za

Biography

I have been teaching in the discipline of Pharmacy Practice at UWC for over 15 years. My teaching and research focus is pharmaceutical public health and medicine supply management. I currently coordinate and teach 3 courses offered in Pharmacy Practice.

Committees served on: Student Support Committee

Recent Publications:
Ncube, B.M., Dube, A., Ward, K. (2021) Establishment of the African Medicines Agency: progress, challenges and regulatory readiness. Journal of Pharmaceutical Policy and Practice, 14(1), 29

Ward K, Suleiman R, Kippie Y & Dube A. (2019).  A post-market quality assessment of first-line, fixed-dose combination antiretrovirals in South Africa. Journal of Applied Pharmaceutical Science, 9(02): 097-104

Ward K. (2019). Engaged learners breed engaged pharmacists.  South African Pharmaceutical Journal, 86(2): 48-51

Odendaal WA, Ward K, Uneke J, Uro-Chukwu H, Chitama D, Balakrishna Y, Kredo T. (2018) Contracting out to improve the use of clinical health services and health outcomes in low- and middle-income countries. Cochrane Database of Systematic Reviews 2018, Issue 4. Art. No.: CD008133. DOI: 10.1002/14651858.CD008133.pub2.

Magadzire BP, Mathole T & Ward K.  (2017). Reasons for missed appointments linked to a public-sector intervention targeting patients with stable chronic conditions in South Africa: results from in-depth interviews and a retrospective review of medical records. BMC Family Practice, 18:82

Magadzire BP, Marchal B, Mathys R, Laing R & Ward K.  (2017). Analyzing implementation dynamics using theory-driven evaluation principles: lessons learnt from a South African centralized chronic dispensing model.  BMC Health Services Research, 17 (Suppl 2):724

Magadzire BP, Ward KL, Leng HMJ & Sanders D. (2017). Inefficient procurement processes undermine access to medicines in the Western Cape Province of South Africa.  South African Medical Journal, 107 (7): 581-584

Magadzire BP, Marchal B & Ward KL.  (2016) Novel models to improve access to medicines for chronic diseases in South Africa: An analysis of stakeholder perspectives on community-based distribution models. Journal of Pharmaceutical Policy and Practice, 9 (1): 28

Magadzire BP, Marchal B & Ward KL.  (2015) Improving access to medicines through centralised dispensing in the public sector: a case study of the Chronic Dispensing Unit in the Western Cape Province, South Africa.  BMC Health Services, 15:513 

Maigetter K, Pollock AM, Kadam A, Ward K & Weiss M.  (2015)  Pharmacovigilance in India, Uganda and South Africa with reference to WHO’s minimum requirements.  Int J Health Policy Manag, 4(x): 1–11

Ward KL, Leng H, Sanders D and Pollock A. (2014). Assessing the geographical distribution equity of community pharmacies in South Africa. Bulletin of the World Health Organisation, 92 (7): 482-489

Magadzire B, Budden A, Ward K and Sanders D. (2014). Frontline Health Workers as Brokers: Provider Perceptions, Experiences and Mitigating Strategies to Improve Access to Medicines.  BMC Health Services Research, 14:520 

Ward, K.L.  (May, 2009).  Evidence Based Pharmacy Practice: Hypercoagulability.  South African Pharmaceutical Journal, 75 (16): 8-17

Ward, K.L.  (October, 2008).  Evidence Based Pharmacy Practice: Urinary Tract Infections.  South African Pharmaceutical Journal, 75 (9): 8-14

Ward, K.L.  (July, 2008).  Evidence Based Pharmacy Practice: Gout.  South African Pharmaceutical Journal, 75(6): 10-16.

Ward K.L. (May, 2008).  Evidence Based Pharmacy Practice: Smoking cessation.  South African Pharmaceutical Journal, 75(4): 8-13.

Ward, K., Butler, N., Mugabo, P., Klausner, J., McFarland, W., Chen, S. and Schwarcz, S.  (2003). Provision of syndromic treatment of sexually transmitted infections by community pharmacists: a potentially underutilized HIV prevention strategy. Sexually Transmitted Disease, 30(8):609-13.
 

Title: Prof

Name and Surname: Samuel Egieyeh

Position: Associate Professor

List of Qualifications: B.Pharm, M.Pharm, PGDipl (Drug Development), PhD (Bioinformatics)

Telephone: 0219593388

Email: segieyeh@uwc.ac.za

Biography

Samuel Ayodele Egieyeh is a seasoned and highly experienced pharmacist (qualified in 1997) with B.Pharm (UNILAG), M.Pharm (UWC) and  PhD in Bioinformatics (UWC). He also has a post-graduate diploma in clinical research and drug development from the University of Basel, Basel Switzerland. 

He started his research career as a research fellow in 2001 at the Department of Pharmaceutics and Pharmaceutical Technology, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja Nigeria where he was involved in the formulation, production and quality control of herbal medicinal products and raw material development. He was later posted to the Antiretroviral Therapy Clinic, in the same institute, as the pharmacist in charge. In 2007, he joined Howard University’s Pharmacy and Continuing Education Centre under the Global HIV/AIDS Initiative Nigeria (GHAIN) project as a Pharmacy Specialist/Monitoring and Evaluation Officer. He joined the International Centre for Genetic Engineering and Biotechnology (ICGEB) Cape Town component where he worked for two years on the development of low-cost technologies for the production of generic biopharmaceuticals. In 2011 he joined the South African Herbal Science and Medicine Institute (SAHSMI) of the University of the Western Cape, where he was involved in the development of herbal products and compilation of product quality brochure for investigational herbal medicinal products. 

He is currently an associate professor at the Discipline of Pharmacology and Clinical Pharmacy, School of Pharmacy, University of the Western Cape, Cape Town South Africa. He leads the Computational Pharmacology and Cheminformatics Group (CPCG). His research focuses on computational drug discovery and design; analysis and interpretation of chemical and bioactivity data using Cheminformatics, Bioinformatics, Machine Learning and Biostatistics techniques in conjunction with relevant in-vitro bioassays in order to discover and design novel drug candidates, especially from natural products, for infectious and non-infectious diseases. As a formulator at heart, he is also involved in the development of novel drug delivery systems for herbal medicine.  Contact: segieyeh@uwc.ac.za, +27 (021) 959 3388, +27843477250.


Committees served on: Research and Equipment


Publications:

Tobeka Naki, William Morwa Reagile Matshe, Mohammed Olusegun Balogun, Suprakas Sinha Ray, Samuel Ayodele Egieyeh & Blessing Atim Aderibigbe (2023) Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer’s disease, Journal of Microencapsulation, 40:1, 15-28, DOI: 10.1080/02652048.2023.2167011
Oselusi SO, Fadaka AO, Wyckoff GJ, Egieyeh SA. Computational Target-Based Screening of Anti-MRSA Natural Products Reveals Potential Multitarget Mechanisms of Action through Peptidoglycan Synthesis Proteins. ACS omega. 2022 Oct 14;7(42):37896-906.
Jadalla, Baraa M. I. S., Justin J. Moser, Rajan Sharma, Ninon G. E. R. Etsassala, Samuel Ayodele Egieyeh, Jelili A. Badmus, Jeanine L. Marnewick, Denzil Beukes, Christopher N. Cupido, and Ahmed A. Hussein. 2022. "In Vitro Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities and Antioxidant Capacity of Helichrysum cymosum and Helichrysum pandurifolium Schrank Constituents" Separations 9, no. 8: 190. https://doi.org/10.3390/separations9080190
Etsassala NGER, Badmus JA, Marnewick JL, Egieyeh S, Iwuoha EI, Nchu F, Hussein AA. Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Plectranthus ecklonii Constituents. Antioxidants (Basel). 2022 Feb 14;11(2). doi: 10.3390/antiox11020378. PubMed PMID: 35204260; PubMed Central PMCID: PMC8869333.

D'Souza S, Du Plessis SM, Egieyeh S, Bekale RB, Maphasa RE, Irabin AF, Sampson SL, Dube A. Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium Tuberculosis. J Pharm Sci. 2022 Feb;111(2):469-478. doi: 10.1016/j.xphs.2021.09.012. Epub 2021 Sep 14. PubMed PMID: 34534573; PubMed Central PMCID: PMC8792347.

Audu O, Stander A, Ajani O, Egieyeh S, October N. In silico design, chemical synthesis and biological screening of novel 4-(1H)-pyridone-based antimalarial agents. Chem Biol Drug Des. 2021 Nov 30;. doi: 10.1111/cbdd.13987. [Epub ahead of print] PubMed PMID: 34850571.

Dube A, Egieyeh S, Balogun M. A Perspective on Nanotechnology and COVID-19 Vaccine Research and Production in South Africa. Viruses. 2021 Oct 18;13(10). doi: 10.3390/v13102095. PubMed PMID: 34696526; PubMed Central PMCID: PMC8539279.

Ntie-Kang F, Telukunta KK, Fobofou SAT, Chukwudi Osamor V, Egieyeh SA, Valli M, Djoumbou-Feunang Y, Sorokina M, Stork C, Mathai N, Zierep P, Chávez-Hernández AL, Duran-Frigola M, Babiaka SB, Tematio Fouedjou R, Eni DB, Akame S, Arreyetta-Bawak AB, Ebob OT, Metuge JA, Bekono BD, Isa MA, Onuku R, Shadrack DM, Musyoka TM, Patil VM, van der Hooft JJJ, da Silva Bolzani V, Medina-Franco JL, Kirchmair J, Weber T, Tastan Bishop Ö, Medema MH, Wessjohann LA, Ludwig-Müller J. Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop. J Cheminform. 2021 Sep 6;13(1):64. doi: 10.1186/s13321-021-00546-8. PubMed PMID: 34488889; PubMed Central PMCID: PMC8419829.

Autamashih, Musa, Naushaad Ebrahim, Samuel Egieyeh, Marique Aucamp, Paulo Cesar Pires Rosa, Madan S. Poka, Jean Baptiste Ngilirabanga, and Halima Samsodien. "4‐in‐1 Multipurpose Excipient from Musa acuminata Fruit by Alkaline‐Steeping/Retrogradation (ASR) in Acetaminophen Tablet Formulation." Starch‐Stärke 73, no. 9-10 (2021): 2100016.


Adesanya, Enitan Omobolanle, Mubo Adeola Sonibare, Edith Oriabure Ajaiyeoba, and Samuel Ayodele Egieyeh. "Compounds isolated from hexane fraction of Alternanthera brasiliensis show synergistic activity against methicillin resistant Staphylococcus aureus." Physical Sciences Reviews (2021).

McCartney, J., S. Egieyeh, N. Ebrahim, E. Braaf, and D. Beukes. "Innovations in Pharmacy Education during the Pandemic: Using Learning Science to support laboratory-based practical skills." SA Pharmaceutical Journal 88, no. 4 (2021): 31-33.

Oselusi SO, Christoffels A, Egieyeh SA. Cheminformatic Characterization of Natural Antimicrobial Products for the Development of New Lead Compounds. Molecules. 2021 Jun 29;26(13). doi: 10.3390/molecules26133970. Review. PubMed PMID: 34209681; PubMed Central PMCID: PMC8271829.

Oselusi SO, Egieyeh SA, Christoffels A. Cheminformatic Profiling and Hit Prioritization of Natural Products with Activities against Methicillin-Resistant Staphylococcus aureus (MRSA). Molecules. 2021 Jun 16;26(12). doi: 10.3390/molecules26123674. PubMed PMID: 34208597; PubMed Central PMCID: PMC8246317.


Egieyeh S, Egieyeh E, Malan S, Christofells A, Fielding B. Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2). PLoS One. 2021;16(1):e0245258. doi: 10.1371/journal.pone.0245258. eCollection 2021. PubMed PMID: 33417604; PubMed Central PMCID: PMC7793299.

Egieyeh, Samuel Ayodele, and Elizabeth Oyebola Egieyeh. "The status of integration of herbal medicines into modern clinical practice and possible development of the market." In Herbal Medicine in Andrology, pp. 227-235. Academic Press, 2021.

Egieyeh, Samuel, Sarel F. Malan, and Alan Christoffels. "Cheminformatics techniques in antimalarial drug discovery and development from natural products 2: Molecular scaffold and machine learning approaches." Physical Sciences Reviews 6, no. 3 (2021).

Egieyeh, Samuel, Sarel F. Malan, and Alan Christoffels. "Cheminformatics techniques in antimalarial drug discovery and development from natural products 1: Basic concepts." Physical Sciences Reviews 4, no. 7 (2019).

Egieyeh S, Syce J, Malan SF, Christoffels A. Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach. PLoS One. 2018;13(9):e0204644. doi: 10.1371/journal.pone.0204644. eCollection 2018. PubMed PMID: 30265702; PubMed Central PMCID: PMC6161899.

Egieyeh SA, Syce J, Malan SF, Christoffels A. Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs. Malar J. 2016 Jan 29;15:50. doi: 10.1186/s12936-016-1087-y. PubMed PMID: 26823078; PubMed Central PMCID: PMC4731946.

Egieyeh S, Syce J, Christoffels A, Malan SF. Exploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data. Molecules. 2016 Jan 16;21(1):104. doi: 10.3390/molecules21010104. PubMed PMID: 26784165; PubMed Central PMCID: PMC6273396.

Builders, P. F., U. Okeke, and A. S. Egieyeh. "Evaluation of the controlled release potential of mucilage: A super gel forming polymer." Journal of Phytomedicine and Therapeutics 12 (2007): 22-30.

Builders, Philip F., Ayo Egeiyeh, Peters Oladosu, and Olubayo O. Kunle. "Quality assessment of some brands of Ciprofloxacin tablets on sale in Abuja, Nigeria." Journal of Pharmacy & Bioresources 2, no. 1 (2005): 49-54.

 

Title: Professor 

Name and Surname: Kenechukwu Obikeze

Position: 

List of Qualifications: 

Telephone: 021 9593665

Email: kobikeze@uwc.ac.za

Biography

Prof Kenechukwu Obikeze obtained his B. Pharmacy degree from the University of Nigeria, and his doctoral degree in Pharmacy from the University of the Western Cape. He has lectured in Pharmacology to pharmacy, dentistry and nursing students at the University of the Western Cape since 2005. Prof Obikeze research focuses on the pharmacological evaluation of traditional medicinal plant extracts and isolated compounds thereof for cardiovascular activity using in vivo, in vitro and in silico techniques. Prof Obikeze is a member of the PSSA, the academy of pharmaceutical sciences of South Africa, the South African Society for Basic and Clinical Pharmacology and is a pharmacology subject specialist for the curriculum evaluation committee of the South African Pharmacy Council

Recent Publications:

Samkange, T., D’Souza, S., Obikeze, K., Dube, A. 2019. Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin. Journal of Pharmacy and Pharmacology; 71(10): 1497-1507htpp://dx.doi.org/10.1111/jphp.13147

Neliswa A. Matrose, Kenechukwu Obikeze, Zinash A. Belay, Oluwafemi J. Caleb. 2020. Plant extracts and other natural compounds as alternatives for post-harvest management of fruit fungal pathogens: A review, Food Bioscience, in press  https://doi.org/10.1016/j.fbio.2020.100840.

Neliswa A. Matrose, Kenechukwu Obikeze, Zinash A. Belay, Oluwafemi J. Caleb. 2021. Impact of spatial variation and extraction solvents on bioactive compounds, secondary metabolites and antifungal efficacy of South African Impepho [Helichrysum odoratissimum (L.) Sweet], Food Bioscience, 42: https://doi.org/10.1016/j.fbio.2021.101139.

Ngqaneka T, Obikeze K, Magwebu ZE, Chauke CG. 2023. Proprotein convertase subtilisin/kexin type 9 genetic screening using the vervet ( Chlorocebus aethiops ) model. Journal of Medical Primatology. 52 (1). Pp 45-52.  doi:10.1111/jmp.12623.

Obikeze K, Gainsford G, Kamaar M, Mbewe R, Palmer M, Wilsnach N. 2022. Crataegus monogyna and Centella asiatica Extracts as Inhibitors of Cathepsin S. Advances in Pharmacology and Pharmacy. Vol. 10(4), pp. 247 - 252. doi:10.13189/app.2022.100403.

‌Matrose, N.; Belay, Z.; Obikeze, K.; Mokwena, L.; Caleb, O.J. 2023. Bioprospecting of Helichrysum species: Chemical Profile, Phytochemical Properties, and Antifungal Efficacy against Botrytis cinerea. Plants, 12, 58.
Obikeze K, Sasi, AA, Raji, I. 2023. In-silico and in-vivo evaluation of the Cardiovascular effects of five Leonotis leonurus diterpenes, Scientific African, Vol. 19. doi.org/10.1016/j.sciaf.2022.e01510.

 spontaneously hypertensive rats. Tropical Journal of Pharmaceutical Research ; 15 (11): 2429-2434    http://dx.doi.org/10.4314/tjpr.v15i11.18

Title:  Dr

Name and Surname: Jane McCartney

Position: Senior Lecturer (Clinical Pharmacy and Pharmacology)

List of Qualifications: PhD, MSc (Pharm), DipPharm

Telephone: 021-9593663

Email: jmccartney@uwc.ac.za

Biography

In August 2018, I joined the School of Pharmacy at the University of Western Cape after more than 20 years of lecturing and research experience at the Department of Pharmacy, Nelson Mandela University. I am currently involved in the Pharmacology and Clinical Pharmacy modules of the BPharm programme at UWC, as well as the development of postgraduate programmes.   
My research interest focuses on the role of the clinically focused pharmacist in the optimisation of medicine use and the implementation of interventions aimed at improving healthcare outcomes at the primary health care level as well as in hospitalised patients. I am also very interested in pharmacy education, with a special focus on experiential learning programmes in the clinical setting. I have experience in both quantitative and qualitative research methodologies.

Recent Publications:
McCartney J and Boschmans S-A. South African pharmacy student perspectives of a hospital- based experiential learning programme. Pharmacy Education, 2018; 18 (1) 29 - 40

Khan Y, McCartney J, Coetzee R and Boschmans S-A. Letter to the Editor: Undergraduate    antimicrobial stewardship training for pharmacy students: creating a foundation for containment of antimicrobial resistance in South Africa. South African Medical Journal 2017:107(9):722. 

Regnart J, McCartney J & Truter I. Drug holiday utilization in ADHD-diagnosed children and adolescents in South Africa. Journal of Child & Adolescent Mental Health 2014: p1-13. 

Wietholter J P, Coetzee R, McCartney J, Gegg J, Schwinghammer T L. Development of an international advanced pharmacy practice experience (APPE) and lessons learned after implementation. Currents in Pharmacy Teaching and Learning. 2014: 6: 304–312.

Title:  Mrs

Name and Surname: Elizabeth Egieyeh

Position:  Associate lecturer

List of Qualifications: B.Pharm, M. Pharm, PGDip in Medicines Development

Telephone: +27219592192

Fax:

Email: eegieyeh@uwc.ac.za

Biography

Elizabeth Egieyeh is pharmacist who obtained a Bachelor of Pharmacy from the University of Lagos, Nigeria. She holds a Master of Pharmacy degree from the University of Western Cape, South Africa where she lectures. Her current research interest is in the SDG targets 3.1, 3.2 and 3.7. Her focus is on improving the contribution of pharmacists to reproductive and sexual health, and maternal and child mortality rate reduction through undergraduate pharmacy curriculum review and development.

Committees served on:
Media and Recruitment

Recent Publications:
EO Egieyeh, A Bheekie, MV Huyssteen, R Coetzee. Development and Implementation of an Integrated Framework for Undergraduate Pharmacy Training in Maternal and Child Health at a South African University. Pharmacy 9 (4), 163. 2021

E Egieyeh, M van Huyssteen, R Coetzee, A Bheekie. Evaluating pharmacy students’ knowledge and skills in reproductive, maternal, new-born and child health care at a South African university. BMC Medical Education 21 (1), 1-16. 2021

S Egieyeh, E Egieyeh, S Malan, A Christofells, B Fielding. Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2). Plos one 16 (1), e0245258. 2021

SA Egieyeh, EO Egieyeh. The status of integration of herbal medicines into modern clinical practice and possible development of the market. Herbal Medicine in Andrology, 227-235. Herbal Medicine in Andrology. R Henkel, A Agarwal. Academic Press. 2020

S Egieyeh, E Egieyeh, U Inyang, D Oqua. Quantitative and qualitative analysis of observed or reported adverse effects from clients on antiretroviral therapy, vis-à-vis gender, current cd4 count and antiretroviral regimen. Basic & Clinical Pharmacology & Toxicology 115. 2014

S Egieyeh, E Egieyeh, U Inyang, D Oqua. Quantitative and qualitative evaluation of medication errors in four antiretroviral therapy (art) outpatient clinics federal capital territory, Nigeria. Basic & Clinical Pharmacology & Toxicology 115, 84-85. 2014
 

Title:  Mrs

Name and Surname: Nicole Keuler (Hoffman)

Position:  Associate Lecturer (Clinical Pharmacy and Pharmacology)

List of Qualifications: B. Pharm

Telephone: 021 959 3382

Fax:

Email: nnkeuler@uwc.ac.za

Biography

Nicole Keuler is a pharmacist, researcher and educator from Cape Town, South Africa who is passionate about teaching. Nicole leads from the domain of relationships building, executing and strategic thinking. 

Nicole is leading the Masters in Clinical Pharmacy programme at the University of the Western Cape. She is passionate about promoting the role of the clinical pharmacist in the healthcare team. Nicole believes that to optimise patient healthcare we need to work in a multidisciplinary team and promote interprofessional collaboration and education at local and international levels. Nicole believes that it is important to bring clinical experience to the class room to enhance the learning experience and quality of teaching.

Her postgraduate teaching is focused on infectious diseases, paediatrics and obstetrics and gynaecology. Her recent research is focused on urinary tract infections and pharmacogenomics.

Nicole is a vaccinator and assists as a volunteer administering COVID-19 vaccines. Nicole is a graduate from Harvard Medical School who completed the Foundations in Clinical Research program in 2022.

Committees served on:
Member, Pharmaceutical Society of South Africa (PSSA)
Member, South African Association of Hospital and Institutional Pharmacists (SAAHIP), Cape Western Province Branch
Chair, Young Pharmacists’ Group of PSSA

Publications:
1. Hoffman NL, Naicker H, Botha A & Coetzee R. 2017. Evaluating the use of nystatin oral drops in a paediatric tertiary hospital in South Africa: A medicine use evaluation. South African Pharmaceutical Journal, 84 (5):66-68.
2. Hoffman NL, Coetzee R. 2019. An evidence-based medicine approach to optimising medication therapy in a patient with Clostridium difficile infection. South African Pharmaceutical Journal. 86 (6):32-34
3. Wehmeyer A, Coetzee R, Hoffman N, Johnson Y & Kloppers R. 2020. Medicine-use evaluation of doxazosin prescribing to inform formulary recommendations. South African Medical Journal. 110 (1):16-20.
4. Viljoen M, Coetzee R, Hoffman N, McCartney J, Upton E & Van Huyssteen M. 2021. Reflection on remote teaching and learning of a final-year BPharm clinical training module during a pandemic. African Journal of Health Professions Education. 13(3)203-204.
5. Keuler N, Bouwer A, Coetzee R. 2021. Pharmacists’ Approach to Optimise Safe Medication Use in Paediatric Patients. Pharmacy. 9(4):180. https://doi.org/10.3390/pharmacy9040180

 

Title:  Mrs

Name and Surname:  Eloise Braaf

Position:  Chief Officer

List of Qualifications: BSc, BSc Hons (Biotechnology), MSc (Biotechnology)

Telephone: 021 959 3387

Email:  ebraaf@uwc.ac.za

Biography

I am Eloise Braaf a Chief Officer in the School of Pharmacy at the University of the Western Cape. I obtained my BSc in Molecular and Cellular Biology from Stellenbosch University and BSc (Hons) and MSc in Biotechnology from the University of the Western Cape. My research experience includes Microbiology, Medical Virology, and Biotechnology. I am the Practical Coordinator for Pharmaceutical Microbiology and my responsibilities include managing all laboratories within the Pharmacology discipline.

Title:  Mr

Name and Surname: Alex Wehmeyer


Position: Lecturer (Pharmacology & Clinical Pharmacy)

List of Qualifications: BPharm, MClinPharm

Telephone: 021 959 2864

Email: awehmeyer@uwc.ac.za

Biography

Alex Wehmeyer is a registered pharmacist and educator with a specialization in clinical pharmacy.
Alex completed his BPharm in 2017 and his MClinPharm in 2021 at the University of the Western Cape. His research interests include clinical pharmacy practice, venous thromboembolism prophylaxis, rural health, community engagement and rational medicine use (RMU).

Committees served on:
  • Member, Pharmaceutical Society of South Africa (PSSA) National Executive Committee.
  • Member, PSSA Cape Western Province Branch.
  • Treasurer, South African Association of Hospital and Institutional
  • Pharmacists (SAAHIP) Cape Western Province Branch.

Title: Mrs

Name and Surname:  Adeola Egunlusi

Position:   Technical Officer

List of Qualifications:  Bachelor of Pharmacy (Nig.). M.Pharmacy (UWC)

Telephone:  021 959 9512

Email:  ategunlusi@uwc.ac.za

Biography

Obtained her B. Pharmacy degree from Obafemi Awolowo University, Nigeria, and her Masters degree in Pharmacy from the University of the Western Cape. She is the Technical officer for the department of Pharmacology and Clinical Pharmacy at the school of Pharmacy, UWC from November 2021 till date.


Research Area: Service learning in Pharmacy (SLiP), Social accountability of Pharmacy students in UWC.
 
Committees served on:

Recent Publications: Adeleye T. Adeola et al., Service learning in Pharmacy: implementation of tuberculosis screening by second-year pharmacy students in primary health care facilities in Cape Town, South Africa. Pharmacy Education (2021) 21(1) 203-215.



 

Title: Ms

Name and Surname: Yasmine Khan

Position:  Pharmacology and Clinical Pharmacy

List of Qualifications:  B.Pharm, M.Pharm

Telephone:  021 959 3882

Email:  ykhan@uwc.ac.za

Biography

Yasmine Khan obtained her B.Pharm and M.Pharm degrees at Nelson Mandela Metropolitan University. She has lectured pharmacology and clinical pharmacy at University of Western Cape since January 2023. Yasmine’s research interests include antimicrobial stewardship, pharmacy education, and interprofessional education and collaborative practice. Yasmine is a member of the PSSA (Academy and SAAHIP sectors), Towards Unity for Health (TUFH) and the South African Society of Clinical Pharmacy (SASOCP).


Research Area: Antimicrobial stewardship, pharmacy education, interprofessional collaboration
 
Committees served on: N/A

Recent Publications:
Khan Y, Boschmans S-A, McCartney J, Coetzee R. Undergraduate antimicrobial stewardship training for pharmacy students: Creating a foundation for containment of antimicrobial resistance in South Africa. South African Med J. 2017;107(9):722. Doi:10.7196/samj.2017.v107i9.12649

Khan Y, Kritiotis L, Coetzee R, McCartney J, Boschmans S. Implementing antimicrobial stewardship in South Africa – how well prepared are pharmacists for their role? South African Pharm J. 2019;86(5):43-46

Khan Y, Kritiotis L, Coetzee R, McCartney J, Boschmans S. The development of a proposed antimicrobial stewardship curriculum for the South African Bachelor of Pharmacy programme. South African Pharm J. 2020;87(2):38-41

Khan Y, Kritiotis L, Coetzee R, McCartney J, Boschmans S. An antimicrobial stewardship curriculum to incorporate in the South African Bachelor of Pharmacy Degree Program. Am J Pharm Educ. 2020;84(7):947-958
 
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